N-Glycan Branching Decouples B Cell Innate and Adaptive Immunity to Control Inflammatory Demyelination

B cell depletion potently reduces episodes of inflammatory demyelination in multiple sclerosis (MS), predominantly through loss of innate rather than adaptive immunity. However, molecular mechanisms controlling innate versus adaptive B cell function are poorly understood. N-glycan branching, via int...

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Detalles Bibliográficos
Autores principales: Mortales, Christie-Lynn, Lee, Sung-Uk, Manousadjian, Armen, Hayama, Ken L., Demetriou, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398982/
https://www.ncbi.nlm.nih.gov/pubmed/32745987
http://dx.doi.org/10.1016/j.isci.2020.101380

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