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Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?

BACKGROUND: Inactive human cathelicidin antimicrobial peptide is present in neutrophils, and proteinase 3 activates this peptide by producing active LL-37 peptide. LL-37 acts as a defensive peptide in the oral tissues. In the present study, the aim was to evaluate LL-37 and proteinase 3 levels in pe...

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Autores principales: Turkoglu, Oya, Efeoglu, Candan, Atmaca, Harika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398999/
https://www.ncbi.nlm.nih.gov/pubmed/32748292
http://dx.doi.org/10.1186/s40729-020-00240-8
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author Turkoglu, Oya
Efeoglu, Candan
Atmaca, Harika
author_facet Turkoglu, Oya
Efeoglu, Candan
Atmaca, Harika
author_sort Turkoglu, Oya
collection PubMed
description BACKGROUND: Inactive human cathelicidin antimicrobial peptide is present in neutrophils, and proteinase 3 activates this peptide by producing active LL-37 peptide. LL-37 acts as a defensive peptide in the oral tissues. In the present study, the aim was to evaluate LL-37 and proteinase 3 levels in peri-implant sulcus fluid (PISF) in implants with and without peri-implantitis. METHODS: Patients who simultaneously had dental implants with peri-implantitis and without peri-implantitis were included in the study. Forty-four samples with peri-implantitis and 34 samples without peri-implantitis from 16 patients were obtained. Intraoral evaluations such as pocket depth, modified sulcus bleeding index, and modified plaque index were noted. Enzyme-linked immunosorbent assay was used for the evaluation of PISF LL-37 and proteinase 3 levels. RESULTS: PISF volume was significantly increased in the implants with peri-implantitis than those without peri-implantitis (p < 0.05). No difference was present between PISF LL-37 and proteinase 3 total amounts between the implants with and without peri-implantitis (p > 0.05). Pocket depths and PISF LL-37 and proteinase 3 levels were not correlated in the groups (p > 0.05). CONCLUSIONS: PISF volume might be increased in response to peri-implant bone destruction. However, peri-implant tissue destruction caused by peri-implantitis does not seem to affect PISF LL-37 and proteinase 3 levels.
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spelling pubmed-73989992020-08-13 Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid? Turkoglu, Oya Efeoglu, Candan Atmaca, Harika Int J Implant Dent Research BACKGROUND: Inactive human cathelicidin antimicrobial peptide is present in neutrophils, and proteinase 3 activates this peptide by producing active LL-37 peptide. LL-37 acts as a defensive peptide in the oral tissues. In the present study, the aim was to evaluate LL-37 and proteinase 3 levels in peri-implant sulcus fluid (PISF) in implants with and without peri-implantitis. METHODS: Patients who simultaneously had dental implants with peri-implantitis and without peri-implantitis were included in the study. Forty-four samples with peri-implantitis and 34 samples without peri-implantitis from 16 patients were obtained. Intraoral evaluations such as pocket depth, modified sulcus bleeding index, and modified plaque index were noted. Enzyme-linked immunosorbent assay was used for the evaluation of PISF LL-37 and proteinase 3 levels. RESULTS: PISF volume was significantly increased in the implants with peri-implantitis than those without peri-implantitis (p < 0.05). No difference was present between PISF LL-37 and proteinase 3 total amounts between the implants with and without peri-implantitis (p > 0.05). Pocket depths and PISF LL-37 and proteinase 3 levels were not correlated in the groups (p > 0.05). CONCLUSIONS: PISF volume might be increased in response to peri-implant bone destruction. However, peri-implant tissue destruction caused by peri-implantitis does not seem to affect PISF LL-37 and proteinase 3 levels. Springer Berlin Heidelberg 2020-08-04 /pmc/articles/PMC7398999/ /pubmed/32748292 http://dx.doi.org/10.1186/s40729-020-00240-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Research
Turkoglu, Oya
Efeoglu, Candan
Atmaca, Harika
Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?
title Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?
title_full Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?
title_fullStr Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?
title_full_unstemmed Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?
title_short Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?
title_sort does peri-implant bone loss affect the ll-37 and proteinase 3 levels in peri-implant sulcus fluid?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398999/
https://www.ncbi.nlm.nih.gov/pubmed/32748292
http://dx.doi.org/10.1186/s40729-020-00240-8
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