Cargando…

Rapidly progressed neuroendocrine carcinoma in the extrahepatic bile duct: a case report and review of the literature

BACKGROUND: Neuroendocrine carcinoma (NEC) originating from the extrahepatic bile duct (EHBD) is very rare but is known for its aggressiveness and poor prognosis. We herein report a case of rapidly progressed NEC in the extrahepatic bile duct. CASE PRESENTATION: An 84-year-old man was referred to ou...

Descripción completa

Detalles Bibliográficos
Autores principales: Kamiya, Mariko, Yamamoto, Naoto, Kamioka, Yuto, Inoue, Hirohide, Yotsumoto, Hirokazu, Murakawa, Masaaki, Aoyama, Toru, Washimi, Kota, Kawachi, Kae, Oshima, Takashi, Ueno, Makoto, Yukawa, Norio, Rino, Yasushi, Masuda, Munetaka, Morinaga, Soichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399003/
https://www.ncbi.nlm.nih.gov/pubmed/32748005
http://dx.doi.org/10.1186/s40792-020-00945-3
_version_ 1783566061506920448
author Kamiya, Mariko
Yamamoto, Naoto
Kamioka, Yuto
Inoue, Hirohide
Yotsumoto, Hirokazu
Murakawa, Masaaki
Aoyama, Toru
Washimi, Kota
Kawachi, Kae
Oshima, Takashi
Ueno, Makoto
Yukawa, Norio
Rino, Yasushi
Masuda, Munetaka
Morinaga, Soichiro
author_facet Kamiya, Mariko
Yamamoto, Naoto
Kamioka, Yuto
Inoue, Hirohide
Yotsumoto, Hirokazu
Murakawa, Masaaki
Aoyama, Toru
Washimi, Kota
Kawachi, Kae
Oshima, Takashi
Ueno, Makoto
Yukawa, Norio
Rino, Yasushi
Masuda, Munetaka
Morinaga, Soichiro
author_sort Kamiya, Mariko
collection PubMed
description BACKGROUND: Neuroendocrine carcinoma (NEC) originating from the extrahepatic bile duct (EHBD) is very rare but is known for its aggressiveness and poor prognosis. We herein report a case of rapidly progressed NEC in the extrahepatic bile duct. CASE PRESENTATION: An 84-year-old man was referred to our facility with obstructive jaundice and abdominal pain. Imaging studies revealed an irregular filling defect in the middle bile duct by endoscopic retrograde cholangiopancreatography and an enhanced wall thickening from the middle to distal portion by enhanced computed tomography. The patient was initially diagnosed with extrahepatic cholangiocarcinoma by a bile duct biopsy and underwent pancreatoduodenectomy with lymph node dissection. The pathological findings showed an NEC with an adenosquamous carcinoma component in the extrahepatic bile duct with lymph node metastases. The patient experienced multiple liver metastases 1 month after surgery and died 3 months after surgery. Due to the rapid progression of his disease, his general condition deteriorated, and he was unable to receive any additional treatments, such as chemotherapy. CONCLUSION: As shown in our case, NEC of the EHBD has an extremely poor prognosis and can sometimes progress rapidly. Multimodality treatment should be considered, even in cases of locoregional disease.
format Online
Article
Text
id pubmed-7399003
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-73990032020-08-13 Rapidly progressed neuroendocrine carcinoma in the extrahepatic bile duct: a case report and review of the literature Kamiya, Mariko Yamamoto, Naoto Kamioka, Yuto Inoue, Hirohide Yotsumoto, Hirokazu Murakawa, Masaaki Aoyama, Toru Washimi, Kota Kawachi, Kae Oshima, Takashi Ueno, Makoto Yukawa, Norio Rino, Yasushi Masuda, Munetaka Morinaga, Soichiro Surg Case Rep Case Report BACKGROUND: Neuroendocrine carcinoma (NEC) originating from the extrahepatic bile duct (EHBD) is very rare but is known for its aggressiveness and poor prognosis. We herein report a case of rapidly progressed NEC in the extrahepatic bile duct. CASE PRESENTATION: An 84-year-old man was referred to our facility with obstructive jaundice and abdominal pain. Imaging studies revealed an irregular filling defect in the middle bile duct by endoscopic retrograde cholangiopancreatography and an enhanced wall thickening from the middle to distal portion by enhanced computed tomography. The patient was initially diagnosed with extrahepatic cholangiocarcinoma by a bile duct biopsy and underwent pancreatoduodenectomy with lymph node dissection. The pathological findings showed an NEC with an adenosquamous carcinoma component in the extrahepatic bile duct with lymph node metastases. The patient experienced multiple liver metastases 1 month after surgery and died 3 months after surgery. Due to the rapid progression of his disease, his general condition deteriorated, and he was unable to receive any additional treatments, such as chemotherapy. CONCLUSION: As shown in our case, NEC of the EHBD has an extremely poor prognosis and can sometimes progress rapidly. Multimodality treatment should be considered, even in cases of locoregional disease. Springer Berlin Heidelberg 2020-08-03 /pmc/articles/PMC7399003/ /pubmed/32748005 http://dx.doi.org/10.1186/s40792-020-00945-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Kamiya, Mariko
Yamamoto, Naoto
Kamioka, Yuto
Inoue, Hirohide
Yotsumoto, Hirokazu
Murakawa, Masaaki
Aoyama, Toru
Washimi, Kota
Kawachi, Kae
Oshima, Takashi
Ueno, Makoto
Yukawa, Norio
Rino, Yasushi
Masuda, Munetaka
Morinaga, Soichiro
Rapidly progressed neuroendocrine carcinoma in the extrahepatic bile duct: a case report and review of the literature
title Rapidly progressed neuroendocrine carcinoma in the extrahepatic bile duct: a case report and review of the literature
title_full Rapidly progressed neuroendocrine carcinoma in the extrahepatic bile duct: a case report and review of the literature
title_fullStr Rapidly progressed neuroendocrine carcinoma in the extrahepatic bile duct: a case report and review of the literature
title_full_unstemmed Rapidly progressed neuroendocrine carcinoma in the extrahepatic bile duct: a case report and review of the literature
title_short Rapidly progressed neuroendocrine carcinoma in the extrahepatic bile duct: a case report and review of the literature
title_sort rapidly progressed neuroendocrine carcinoma in the extrahepatic bile duct: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399003/
https://www.ncbi.nlm.nih.gov/pubmed/32748005
http://dx.doi.org/10.1186/s40792-020-00945-3
work_keys_str_mv AT kamiyamariko rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT yamamotonaoto rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT kamiokayuto rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT inouehirohide rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT yotsumotohirokazu rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT murakawamasaaki rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT aoyamatoru rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT washimikota rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT kawachikae rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT oshimatakashi rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT uenomakoto rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT yukawanorio rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT rinoyasushi rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT masudamunetaka rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature
AT morinagasoichiro rapidlyprogressedneuroendocrinecarcinomaintheextrahepaticbileductacasereportandreviewoftheliterature