Early Adjuvant Medication With the mTOR Inhibitor Sirolimus in a Preterm Neonate With Compressive Cystic Lymphatic Malformation

Cystic lymphatic malformations result from an abnormal embryological development of the lymphatic structures. Here we report on a case of a preterm female baby, born at 34 weeks of gestation, with a voluminous cervicofacial cystic lymphatic malformation responsible for an airway obstruction. An mTOR...

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Autores principales: Honnorat, Marion, Viremouneix, Loïc, Ayari, Sonia, Guibaud, Laurent, Coste, Karen, Claris, Olivier, Butin, Marine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399047/
https://www.ncbi.nlm.nih.gov/pubmed/32850534
http://dx.doi.org/10.3389/fped.2020.00418
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author Honnorat, Marion
Viremouneix, Loïc
Ayari, Sonia
Guibaud, Laurent
Coste, Karen
Claris, Olivier
Butin, Marine
author_facet Honnorat, Marion
Viremouneix, Loïc
Ayari, Sonia
Guibaud, Laurent
Coste, Karen
Claris, Olivier
Butin, Marine
author_sort Honnorat, Marion
collection PubMed
description Cystic lymphatic malformations result from an abnormal embryological development of the lymphatic structures. Here we report on a case of a preterm female baby, born at 34 weeks of gestation, with a voluminous cervicofacial cystic lymphatic malformation responsible for an airway obstruction. An mTOR inhibitor, sirolimus, was started from the first day of life, and was combined with iterative sclerotherapy procedures. This case illustrates a safe and successful early administration of sirolimus in a preterm neonate.
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spelling pubmed-73990472020-08-25 Early Adjuvant Medication With the mTOR Inhibitor Sirolimus in a Preterm Neonate With Compressive Cystic Lymphatic Malformation Honnorat, Marion Viremouneix, Loïc Ayari, Sonia Guibaud, Laurent Coste, Karen Claris, Olivier Butin, Marine Front Pediatr Pediatrics Cystic lymphatic malformations result from an abnormal embryological development of the lymphatic structures. Here we report on a case of a preterm female baby, born at 34 weeks of gestation, with a voluminous cervicofacial cystic lymphatic malformation responsible for an airway obstruction. An mTOR inhibitor, sirolimus, was started from the first day of life, and was combined with iterative sclerotherapy procedures. This case illustrates a safe and successful early administration of sirolimus in a preterm neonate. Frontiers Media S.A. 2020-07-28 /pmc/articles/PMC7399047/ /pubmed/32850534 http://dx.doi.org/10.3389/fped.2020.00418 Text en Copyright © 2020 Honnorat, Viremouneix, Ayari, Guibaud, Coste, Claris and Butin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Honnorat, Marion
Viremouneix, Loïc
Ayari, Sonia
Guibaud, Laurent
Coste, Karen
Claris, Olivier
Butin, Marine
Early Adjuvant Medication With the mTOR Inhibitor Sirolimus in a Preterm Neonate With Compressive Cystic Lymphatic Malformation
title Early Adjuvant Medication With the mTOR Inhibitor Sirolimus in a Preterm Neonate With Compressive Cystic Lymphatic Malformation
title_full Early Adjuvant Medication With the mTOR Inhibitor Sirolimus in a Preterm Neonate With Compressive Cystic Lymphatic Malformation
title_fullStr Early Adjuvant Medication With the mTOR Inhibitor Sirolimus in a Preterm Neonate With Compressive Cystic Lymphatic Malformation
title_full_unstemmed Early Adjuvant Medication With the mTOR Inhibitor Sirolimus in a Preterm Neonate With Compressive Cystic Lymphatic Malformation
title_short Early Adjuvant Medication With the mTOR Inhibitor Sirolimus in a Preterm Neonate With Compressive Cystic Lymphatic Malformation
title_sort early adjuvant medication with the mtor inhibitor sirolimus in a preterm neonate with compressive cystic lymphatic malformation
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399047/
https://www.ncbi.nlm.nih.gov/pubmed/32850534
http://dx.doi.org/10.3389/fped.2020.00418
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