Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis

The interleukin (IL)-17 family includes six structure-related cytokines (A–F). To date, majority of studies have focused on IL-17A. IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. Several recent studies have indicated that IL-17A is a bi...

Descripción completa

Detalles Bibliográficos
Autores principales: Ge, Yun, Huang, Man, Yao, Yong-ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399097/
https://www.ncbi.nlm.nih.gov/pubmed/32849528
http://dx.doi.org/10.3389/fimmu.2020.01558
_version_ 1783566083183083520
author Ge, Yun
Huang, Man
Yao, Yong-ming
author_facet Ge, Yun
Huang, Man
Yao, Yong-ming
author_sort Ge, Yun
collection PubMed
description The interleukin (IL)-17 family includes six structure-related cytokines (A–F). To date, majority of studies have focused on IL-17A. IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. Several recent studies have indicated that IL-17A is a biomarker as well as a therapeutic target in sepsis. In the current review, we summarize the biological functions of IL-17, including IL-17-mediated responses and signal transduction pathways, with particular emphasis on clinical relevance to sepsis.
format Online
Article
Text
id pubmed-7399097
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-73990972020-08-25 Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis Ge, Yun Huang, Man Yao, Yong-ming Front Immunol Immunology The interleukin (IL)-17 family includes six structure-related cytokines (A–F). To date, majority of studies have focused on IL-17A. IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. Several recent studies have indicated that IL-17A is a biomarker as well as a therapeutic target in sepsis. In the current review, we summarize the biological functions of IL-17, including IL-17-mediated responses and signal transduction pathways, with particular emphasis on clinical relevance to sepsis. Frontiers Media S.A. 2020-07-28 /pmc/articles/PMC7399097/ /pubmed/32849528 http://dx.doi.org/10.3389/fimmu.2020.01558 Text en Copyright © 2020 Ge, Huang and Yao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ge, Yun
Huang, Man
Yao, Yong-ming
Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis
title Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis
title_full Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis
title_fullStr Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis
title_full_unstemmed Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis
title_short Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis
title_sort biology of interleukin-17 and its pathophysiological significance in sepsis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399097/
https://www.ncbi.nlm.nih.gov/pubmed/32849528
http://dx.doi.org/10.3389/fimmu.2020.01558
work_keys_str_mv AT geyun biologyofinterleukin17anditspathophysiologicalsignificanceinsepsis
AT huangman biologyofinterleukin17anditspathophysiologicalsignificanceinsepsis
AT yaoyongming biologyofinterleukin17anditspathophysiologicalsignificanceinsepsis

Ejemplares similares