Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors

In the past decade, mesenchymal stem cells (MSCs) tend to exhibit inherent tropism for refractory inflammatory diseases and engineered MSCs have appeared on the market as therapeutic agents. Recently, engineered MSCs target to cell surface molecules on immune cells has been a new strategy to improve...

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Autores principales: Liu, Siyu, Liu, Fei, Zhou, You, Jin, Baeku, Sun, Qiang, Guo, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399134/
https://www.ncbi.nlm.nih.gov/pubmed/32849489
http://dx.doi.org/10.3389/fimmu.2020.01076
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author Liu, Siyu
Liu, Fei
Zhou, You
Jin, Baeku
Sun, Qiang
Guo, Shu
author_facet Liu, Siyu
Liu, Fei
Zhou, You
Jin, Baeku
Sun, Qiang
Guo, Shu
author_sort Liu, Siyu
collection PubMed
description In the past decade, mesenchymal stem cells (MSCs) tend to exhibit inherent tropism for refractory inflammatory diseases and engineered MSCs have appeared on the market as therapeutic agents. Recently, engineered MSCs target to cell surface molecules on immune cells has been a new strategy to improve MSC applications. In this review, we discuss the roles of multiple receptors (ICAM-1, Gal-9, PD-L1, TIGIT, CD200, and CXCR4) in the process of MSCs' immunosuppressive properties. Furthermore, we discuss the principles and strategies for developing receptor-regulated MSCs and their mechanisms of action and the challenges of using MSCs as immunosuppressive therapies.
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spelling pubmed-73991342020-08-25 Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors Liu, Siyu Liu, Fei Zhou, You Jin, Baeku Sun, Qiang Guo, Shu Front Immunol Immunology In the past decade, mesenchymal stem cells (MSCs) tend to exhibit inherent tropism for refractory inflammatory diseases and engineered MSCs have appeared on the market as therapeutic agents. Recently, engineered MSCs target to cell surface molecules on immune cells has been a new strategy to improve MSC applications. In this review, we discuss the roles of multiple receptors (ICAM-1, Gal-9, PD-L1, TIGIT, CD200, and CXCR4) in the process of MSCs' immunosuppressive properties. Furthermore, we discuss the principles and strategies for developing receptor-regulated MSCs and their mechanisms of action and the challenges of using MSCs as immunosuppressive therapies. Frontiers Media S.A. 2020-07-28 /pmc/articles/PMC7399134/ /pubmed/32849489 http://dx.doi.org/10.3389/fimmu.2020.01076 Text en Copyright © 2020 Liu, Liu, Zhou, Jin, Sun and Guo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liu, Siyu
Liu, Fei
Zhou, You
Jin, Baeku
Sun, Qiang
Guo, Shu
Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors
title Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors
title_full Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors
title_fullStr Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors
title_full_unstemmed Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors
title_short Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors
title_sort immunosuppressive property of mscs mediated by cell surface receptors
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399134/
https://www.ncbi.nlm.nih.gov/pubmed/32849489
http://dx.doi.org/10.3389/fimmu.2020.01076
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