Down-Regulation of miR-301a-3p Reduces Burn-Induced Vascular Endothelial Apoptosis by potentiating hMSC-Secreted IGF-1 and PI3K/Akt/FOXO3a Pathway

Vascular endothelium dysfunction plays a pivotal role in the initiation and progression of multiple organ dysfunction. The mesenchymal stem cell (MSC) maintains vascular endothelial barrier survival via secreting bioactive factors. However, the mechanism of human umbilical cord MSC (hMSC) in protect...

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Detalles Bibliográficos
Autores principales: Liu, Lingying, Yin, Huinan, Hao, Xingxia, Song, Huifeng, Chai, Jiake, Duan, Hongjie, Chang, Yang, Yang, Longlong, Wu, Yushou, Han, Shaofang, Wang, Xiaoteng, Yue, Xiaotong, Chi, Yunfei, Liu, Wei, Wang, Qiong, Wang, Hongyu, Bai, Hailiang, Shi, Xiuxiu, Li, Shaozeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399190/
https://www.ncbi.nlm.nih.gov/pubmed/32745988
http://dx.doi.org/10.1016/j.isci.2020.101383

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