Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance

OBJECTIVE: PARKIN is an E3 ubiquitin ligase that regulates mitochondrial quality control through a process called mitophagy. Recent human and rodent studies suggest that loss of hepatic mitophagy may occur during the pathogenesis of obesity-associated fatty liver and contribute to changes in mitocho...

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Detalles Bibliográficos
Autores principales: Edmunds, Lia R., Xie, Bingxian, Mills, Amanda M., Huckestein, Brydie R., Undamatla, Ramya, Murali, Anjana, Pangburn, Martha M., Martin, James, Sipula, Ian, Kaufman, Brett A., Scott, Iain, Jurczak, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399260/
https://www.ncbi.nlm.nih.gov/pubmed/32653576
http://dx.doi.org/10.1016/j.molmet.2020.101051

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