The profile of urinary lipid metabolites in cats

Polyunsaturated fatty acids including arachidonic acid (AA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are converted to lipid mediators by oxidation. Unlike other mammals, cats cannot synthesize AA. Since their lipid metabolic features remain unknown, we qualitatively analyzed 118...

Descripción completa

Detalles Bibliográficos
Autores principales: KOBAYASHI, Yui, NAKAMURA, Tatsuro, KOBAYASHI, Koji, MURATA, Takahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399318/
https://www.ncbi.nlm.nih.gov/pubmed/32507833
http://dx.doi.org/10.1292/jvms.20-0238
_version_ 1783566121137340416
author KOBAYASHI, Yui
NAKAMURA, Tatsuro
KOBAYASHI, Koji
MURATA, Takahisa
author_facet KOBAYASHI, Yui
NAKAMURA, Tatsuro
KOBAYASHI, Koji
MURATA, Takahisa
author_sort KOBAYASHI, Yui
collection PubMed
description Polyunsaturated fatty acids including arachidonic acid (AA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are converted to lipid mediators by oxidation. Unlike other mammals, cats cannot synthesize AA. Since their lipid metabolic features remain unknown, we qualitatively analyzed 118 types of urinary lipid metabolites in healthy neutered cats. Using LC-MS, we found 26 lipid metabolites in urines of all individuals. In detail, 20 AA-, 5 EPA- and 1 DHA-derived lipid mediators were detected. Focusing on oxidative pathway, 17 cyclooxygenase-metabolites and 5 metabolites produced by non-enzymatic pathway were detected. Of interest, few lipoxygenase- or cytochrome P450-metabolites were excreted. Thus, AA-derived cyclooxygenase-metabolites mainly composed the urinary lipid metabolites in cats.
format Online
Article
Text
id pubmed-7399318
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Japanese Society of Veterinary Science
record_format MEDLINE/PubMed
spelling pubmed-73993182020-08-06 The profile of urinary lipid metabolites in cats KOBAYASHI, Yui NAKAMURA, Tatsuro KOBAYASHI, Koji MURATA, Takahisa J Vet Med Sci Physiology Polyunsaturated fatty acids including arachidonic acid (AA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are converted to lipid mediators by oxidation. Unlike other mammals, cats cannot synthesize AA. Since their lipid metabolic features remain unknown, we qualitatively analyzed 118 types of urinary lipid metabolites in healthy neutered cats. Using LC-MS, we found 26 lipid metabolites in urines of all individuals. In detail, 20 AA-, 5 EPA- and 1 DHA-derived lipid mediators were detected. Focusing on oxidative pathway, 17 cyclooxygenase-metabolites and 5 metabolites produced by non-enzymatic pathway were detected. Of interest, few lipoxygenase- or cytochrome P450-metabolites were excreted. Thus, AA-derived cyclooxygenase-metabolites mainly composed the urinary lipid metabolites in cats. The Japanese Society of Veterinary Science 2020-06-05 2020-07 /pmc/articles/PMC7399318/ /pubmed/32507833 http://dx.doi.org/10.1292/jvms.20-0238 Text en ©2020 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Physiology
KOBAYASHI, Yui
NAKAMURA, Tatsuro
KOBAYASHI, Koji
MURATA, Takahisa
The profile of urinary lipid metabolites in cats
title The profile of urinary lipid metabolites in cats
title_full The profile of urinary lipid metabolites in cats
title_fullStr The profile of urinary lipid metabolites in cats
title_full_unstemmed The profile of urinary lipid metabolites in cats
title_short The profile of urinary lipid metabolites in cats
title_sort profile of urinary lipid metabolites in cats
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399318/
https://www.ncbi.nlm.nih.gov/pubmed/32507833
http://dx.doi.org/10.1292/jvms.20-0238
work_keys_str_mv AT kobayashiyui theprofileofurinarylipidmetabolitesincats
AT nakamuratatsuro theprofileofurinarylipidmetabolitesincats
AT kobayashikoji theprofileofurinarylipidmetabolitesincats
AT muratatakahisa theprofileofurinarylipidmetabolitesincats
AT kobayashiyui profileofurinarylipidmetabolitesincats
AT nakamuratatsuro profileofurinarylipidmetabolitesincats
AT kobayashikoji profileofurinarylipidmetabolitesincats
AT muratatakahisa profileofurinarylipidmetabolitesincats

Ejemplares similares