Cargando…

From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson’s Disease: Lessons From LRRK2

The pathogenesis of Parkinson’s disease (PD) is thought to rely on a complex interaction between the patient’s genetic background and a variety of largely unknown environmental factors. In this scenario, the investigation of the genetic bases underlying familial PD could unveil key molecular pathway...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mancini, Andrea, Mazzocchetti, Petra, Sciaccaluga, Miriam, Megaro, Alfredo, Bellingacci, Laura, Beccano-Kelly, Dayne A., Di Filippo, Massimiliano, Tozzi, Alessandro, Calabresi, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399363/ https://www.ncbi.nlm.nih.gov/pubmed/32848606 http://dx.doi.org/10.3389/fncel.2020.00158

Ejemplares similares

Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson’s disease
por: Tozzi, Alessandro, et al.
Publicado: (2018)

Synaptic Dysfunction in Multiple Sclerosis: A Red Thread from Inflammation to Network Disconnection
por: Bellingacci, Laura, et al.
Publicado: (2021)

Dopamine-dependent early synaptic and motor dysfunctions induced by α-synuclein in the nigrostriatal circuit
por: Tozzi, Alessandro, et al.
Publicado: (2021)

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice
por: Beccano-Kelly, Dayne A., et al.
Publicado: (2014)

An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?
por: Sciaccaluga, Miriam, et al.
Publicado: (2021)

Cytokines, synaptic plasticity and network dynamics: a matter of balance
por: Bellingacci, Laura, et al.
Publicado: (2023)

Rapid Estrogenic and Androgenic Neurosteroids Effects in the Induction of Long-Term Synaptic Changes: Implication for Early Memory Formation
por: Tozzi, Alessandro, et al.
Publicado: (2020)

Bidirectional Synaptic Plasticity Is Driven by Sex Neurosteroids Targeting Estrogen and Androgen Receptors in Hippocampal CA1 Pyramidal Neurons
por: Tozzi, Alessandro, et al.
Publicado: (2019)

Leptin: A Novel Therapeutic Target in Alzheimer's Disease?
por: Beccano-Kelly, Dayne, et al.
Publicado: (2012)

Editorial: Homeostatic Synaptic Plasticity: From Synaptic Circuit Assembly to Neurological Disorders
por: Letellier, Mathieu, et al.
Publicado: (2021)

Endocannabinoid Signaling Contributes to Experience-Induced Increase of Synaptic Release Sites From Parvalbumin Interneurons in Mouse Visual Cortex
por: Huang, Shiyong, et al.
Publicado: (2020)

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice
por: Volta, Mattia, et al.
Publicado: (2017)

Upregulation of LRRK2 following traumatic brain injury does not directly phosphorylate Thr(175) tau
por: Donison, Neil, et al.
Publicado: (2023)

TNF-Mediated Homeostatic Synaptic Plasticity: From in vitro to in vivo Models
por: Heir, Renu, et al.
Publicado: (2020)

Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system
por: Tozzi, Alessandro, et al.
Publicado: (2015)

LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction
por: Penney, Jay, et al.
Publicado: (2016)

Neuro-Immune Cross-Talk in the Striatum: From Basal Ganglia Physiology to Circuit Dysfunction
por: Mancini, Andrea, et al.
Publicado: (2021)

Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations
por: Labrador-Garrido, Adahir, et al.
Publicado: (2023)

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
por: Cirnaru, Maria D., et al.
Publicado: (2014)

Commentary on “Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice”
por: Popugaeva, Elena, et al.
Publicado: (2014)

Editorial: Synaptic Loss and Neurodegeneration
por: Subramanian, Jaichandar, et al.
Publicado: (2021)

Corrigendum: Synaptic Ribbon Active Zones in Cone Photoreceptors Operate Independently From One Another
por: Grassmeyer, Justin J., et al.
Publicado: (2019)

G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses
por: Ho, Dong Hwan, et al.
Publicado: (2019)

Impaired dopamine release in Parkinson’s disease
por: Cramb, Kaitlyn M L, et al.
Publicado: (2023)

Synaptic Plasticity in Cortical Inhibitory Neurons: What Mechanisms May Help to Balance Synaptic Weight Changes?
por: Bannon, Nicholas M., et al.
Publicado: (2020)

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration
por: Ghiglieri, Veronica, et al.
Publicado: (2018)

Valproic Acid and Epilepsy: From Molecular Mechanisms to Clinical Evidences
por: Romoli, Michele, et al.
Publicado: (2019)

Chronic and Acute Manipulation of Cortical Glutamate Transmission Induces Structural and Synaptic Changes in Co-cultured Striatal Neurons
por: Kuhlmann, Naila, et al.
Publicado: (2021)

Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release
por: Burley, Sarah, et al.
Publicado: (2022)

Synaptic Function and Dysfunction in Lysosomal Storage Diseases
por: Rebiai, Rima, et al.
Publicado: (2021)

Neuroprotective Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells From Different Donors on Spinal Cord Injury in Mice
por: Zhu, Xu, et al.
Publicado: (2022)

Maternal Immune Activation Affects Hippocampal Excitatory and Inhibitory Synaptic Transmission in Offspring From an Early Developmental Period to Adulthood
por: Nakagawa, Keiju, et al.
Publicado: (2020)

Artificial sleep-like up/down-states induce synaptic plasticity in cortical neurons from mouse brain slices
por: Besing, Gai-Linn Kay, et al.
Publicado: (2022)

RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors
por: Dou, Dan, et al.
Publicado: (2023)

Intracellular Trafficking Mechanisms of Synaptic Dysfunction in Alzheimer’s Disease
por: Perdigão, Catarina, et al.
Publicado: (2020)

Homeostatic Depression Shows Heightened Sensitivity to Synaptic Calcium
por: Yeates, Catherine J., et al.
Publicado: (2021)

The MeshCODE to scale—visualising synaptic binary information
por: Barnett, Samuel F. H., et al.
Publicado: (2022)

Editorial: Recent advances in measuring and controlling synaptic communication
por: Lamanna, Jacopo, et al.
Publicado: (2023)

Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice
por: Giesert, Florian, et al.
Publicado: (2013)

An “Outside-In” and “Inside-Out” Consideration of Complement in the Multiple Sclerosis Brain: Lessons From Development and Neurodegenerative Diseases
por: Morgan, B. Paul, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lpittnb3n9gcvc292usrd197mb