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MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment

PURPOSE: This study was performed to examine the usefulness of subscores on the Mini-Mental State Examination (MMSE) for predicting the progression of Alzheimer’s disease (AD) dementia in individuals with mild cognitive impairment (MCI). PATIENTS AND METHODS: A total of 306 MCI individuals in the Al...

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Autores principales: Choe, Young Min, Lee, Boung Chul, Choi, Ihn-Geun, Suh, Guk-Hee, Lee, Dong Young, Kim, Jee Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399468/
https://www.ncbi.nlm.nih.gov/pubmed/32801712
http://dx.doi.org/10.2147/NDT.S263702
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author Choe, Young Min
Lee, Boung Chul
Choi, Ihn-Geun
Suh, Guk-Hee
Lee, Dong Young
Kim, Jee Wook
author_facet Choe, Young Min
Lee, Boung Chul
Choi, Ihn-Geun
Suh, Guk-Hee
Lee, Dong Young
Kim, Jee Wook
author_sort Choe, Young Min
collection PubMed
description PURPOSE: This study was performed to examine the usefulness of subscores on the Mini-Mental State Examination (MMSE) for predicting the progression of Alzheimer’s disease (AD) dementia in individuals with mild cognitive impairment (MCI). PATIENTS AND METHODS: A total of 306 MCI individuals in the Alzheimer’s Disease Neuroimaging Initiative database were included in the study. Standardized clinical and neuropsychological tests were performed at baseline and at 2-year follow-up. Logistic regression analysis was conducted to examine the MMSE total and subscale scores to predict progression to AD dementia in MCI individuals. RESULTS: The MMSE total score and the MMSE memory, orientation, and construction subscores were inversely associated with AD progression after controlling for all potential confounders; MMSE attention and language subscores were not correlated with AD progression. The MMSE delayed recall score among the MMSE memory subscores and the MMSE time score among the orientation subscores, especially week and day, were inversely associated with AD progression; the MMSE immediate recall and place scores were not correlated with progression. CONCLUSION: Our findings suggest that the MMSE memory, orientation, and construction subscores, which are simple and readily available clinical measures, could provide useful information to predict AD dementia progression in MCI individuals in practical clinical settings.
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spelling pubmed-73994682020-08-14 MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment Choe, Young Min Lee, Boung Chul Choi, Ihn-Geun Suh, Guk-Hee Lee, Dong Young Kim, Jee Wook Neuropsychiatr Dis Treat Original Research PURPOSE: This study was performed to examine the usefulness of subscores on the Mini-Mental State Examination (MMSE) for predicting the progression of Alzheimer’s disease (AD) dementia in individuals with mild cognitive impairment (MCI). PATIENTS AND METHODS: A total of 306 MCI individuals in the Alzheimer’s Disease Neuroimaging Initiative database were included in the study. Standardized clinical and neuropsychological tests were performed at baseline and at 2-year follow-up. Logistic regression analysis was conducted to examine the MMSE total and subscale scores to predict progression to AD dementia in MCI individuals. RESULTS: The MMSE total score and the MMSE memory, orientation, and construction subscores were inversely associated with AD progression after controlling for all potential confounders; MMSE attention and language subscores were not correlated with AD progression. The MMSE delayed recall score among the MMSE memory subscores and the MMSE time score among the orientation subscores, especially week and day, were inversely associated with AD progression; the MMSE immediate recall and place scores were not correlated with progression. CONCLUSION: Our findings suggest that the MMSE memory, orientation, and construction subscores, which are simple and readily available clinical measures, could provide useful information to predict AD dementia progression in MCI individuals in practical clinical settings. Dove 2020-07-24 /pmc/articles/PMC7399468/ /pubmed/32801712 http://dx.doi.org/10.2147/NDT.S263702 Text en © 2020 Choe et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Choe, Young Min
Lee, Boung Chul
Choi, Ihn-Geun
Suh, Guk-Hee
Lee, Dong Young
Kim, Jee Wook
MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment
title MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment
title_full MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment
title_fullStr MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment
title_full_unstemmed MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment
title_short MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment
title_sort mmse subscale scores as useful predictors of ad conversion in mild cognitive impairment
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399468/
https://www.ncbi.nlm.nih.gov/pubmed/32801712
http://dx.doi.org/10.2147/NDT.S263702
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