Cargando…
MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment
PURPOSE: This study was performed to examine the usefulness of subscores on the Mini-Mental State Examination (MMSE) for predicting the progression of Alzheimer’s disease (AD) dementia in individuals with mild cognitive impairment (MCI). PATIENTS AND METHODS: A total of 306 MCI individuals in the Al...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399468/ https://www.ncbi.nlm.nih.gov/pubmed/32801712 http://dx.doi.org/10.2147/NDT.S263702 |
_version_ | 1783566156447088640 |
---|---|
author | Choe, Young Min Lee, Boung Chul Choi, Ihn-Geun Suh, Guk-Hee Lee, Dong Young Kim, Jee Wook |
author_facet | Choe, Young Min Lee, Boung Chul Choi, Ihn-Geun Suh, Guk-Hee Lee, Dong Young Kim, Jee Wook |
author_sort | Choe, Young Min |
collection | PubMed |
description | PURPOSE: This study was performed to examine the usefulness of subscores on the Mini-Mental State Examination (MMSE) for predicting the progression of Alzheimer’s disease (AD) dementia in individuals with mild cognitive impairment (MCI). PATIENTS AND METHODS: A total of 306 MCI individuals in the Alzheimer’s Disease Neuroimaging Initiative database were included in the study. Standardized clinical and neuropsychological tests were performed at baseline and at 2-year follow-up. Logistic regression analysis was conducted to examine the MMSE total and subscale scores to predict progression to AD dementia in MCI individuals. RESULTS: The MMSE total score and the MMSE memory, orientation, and construction subscores were inversely associated with AD progression after controlling for all potential confounders; MMSE attention and language subscores were not correlated with AD progression. The MMSE delayed recall score among the MMSE memory subscores and the MMSE time score among the orientation subscores, especially week and day, were inversely associated with AD progression; the MMSE immediate recall and place scores were not correlated with progression. CONCLUSION: Our findings suggest that the MMSE memory, orientation, and construction subscores, which are simple and readily available clinical measures, could provide useful information to predict AD dementia progression in MCI individuals in practical clinical settings. |
format | Online Article Text |
id | pubmed-7399468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-73994682020-08-14 MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment Choe, Young Min Lee, Boung Chul Choi, Ihn-Geun Suh, Guk-Hee Lee, Dong Young Kim, Jee Wook Neuropsychiatr Dis Treat Original Research PURPOSE: This study was performed to examine the usefulness of subscores on the Mini-Mental State Examination (MMSE) for predicting the progression of Alzheimer’s disease (AD) dementia in individuals with mild cognitive impairment (MCI). PATIENTS AND METHODS: A total of 306 MCI individuals in the Alzheimer’s Disease Neuroimaging Initiative database were included in the study. Standardized clinical and neuropsychological tests were performed at baseline and at 2-year follow-up. Logistic regression analysis was conducted to examine the MMSE total and subscale scores to predict progression to AD dementia in MCI individuals. RESULTS: The MMSE total score and the MMSE memory, orientation, and construction subscores were inversely associated with AD progression after controlling for all potential confounders; MMSE attention and language subscores were not correlated with AD progression. The MMSE delayed recall score among the MMSE memory subscores and the MMSE time score among the orientation subscores, especially week and day, were inversely associated with AD progression; the MMSE immediate recall and place scores were not correlated with progression. CONCLUSION: Our findings suggest that the MMSE memory, orientation, and construction subscores, which are simple and readily available clinical measures, could provide useful information to predict AD dementia progression in MCI individuals in practical clinical settings. Dove 2020-07-24 /pmc/articles/PMC7399468/ /pubmed/32801712 http://dx.doi.org/10.2147/NDT.S263702 Text en © 2020 Choe et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Choe, Young Min Lee, Boung Chul Choi, Ihn-Geun Suh, Guk-Hee Lee, Dong Young Kim, Jee Wook MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment |
title | MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment |
title_full | MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment |
title_fullStr | MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment |
title_full_unstemmed | MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment |
title_short | MMSE Subscale Scores as Useful Predictors of AD Conversion in Mild Cognitive Impairment |
title_sort | mmse subscale scores as useful predictors of ad conversion in mild cognitive impairment |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399468/ https://www.ncbi.nlm.nih.gov/pubmed/32801712 http://dx.doi.org/10.2147/NDT.S263702 |
work_keys_str_mv | AT choeyoungmin mmsesubscalescoresasusefulpredictorsofadconversioninmildcognitiveimpairment AT leeboungchul mmsesubscalescoresasusefulpredictorsofadconversioninmildcognitiveimpairment AT choiihngeun mmsesubscalescoresasusefulpredictorsofadconversioninmildcognitiveimpairment AT suhgukhee mmsesubscalescoresasusefulpredictorsofadconversioninmildcognitiveimpairment AT leedongyoung mmsesubscalescoresasusefulpredictorsofadconversioninmildcognitiveimpairment AT kimjeewook mmsesubscalescoresasusefulpredictorsofadconversioninmildcognitiveimpairment AT mmsesubscalescoresasusefulpredictorsofadconversioninmildcognitiveimpairment |