Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer’s Disease Patients

Familial Alzheimer’s Disease (FAD) caused by Presenilin-1 (PS1) mutations is characterized by early onset, cognitive impairment, and dementia. Impaired gamma secretase function favors production of longer beta-amyloid species in PS1 FAD. The PS1 E280A mutation is the largest FAD kindred under study....

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Detalles Bibliográficos
Autores principales: Dinkel, Felix, Trujillo-Rodriguez, Diana, Villegas, Andres, Streffer, Johannes, Mercken, Marc, Lopera, Francisco, Glatzel, Markus, Sepulveda-Falla, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399638/
https://www.ncbi.nlm.nih.gov/pubmed/32848702
http://dx.doi.org/10.3389/fnagi.2020.00220

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