Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart

In heart failure, a functional block of complex I of the respiratory chain provokes superoxide generation, which is transformed to H(2)O(2) by dismutation. The Krebs cycle produces NADH, which delivers electrons to complex I, and NADPH for H(2)O(2) elimination via isocitrate dehydrogenase and nicoti...

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Detalles Bibliográficos
Autores principales: Wagner, Michael, Bertero, Edoardo, Nickel, Alexander, Kohlhaas, Michael, Gibson, Gary E., Heggermont, Ward, Heymans, Stephane, Maack, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399685/
https://www.ncbi.nlm.nih.gov/pubmed/32748289
http://dx.doi.org/10.1007/s00395-020-0815-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399685/
https://www.ncbi.nlm.nih.gov/pubmed/32748289
http://dx.doi.org/10.1007/s00395-020-0815-1

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