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Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart
In heart failure, a functional block of complex I of the respiratory chain provokes superoxide generation, which is transformed to H(2)O(2) by dismutation. The Krebs cycle produces NADH, which delivers electrons to complex I, and NADPH for H(2)O(2) elimination via isocitrate dehydrogenase and nicoti...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399685/ https://www.ncbi.nlm.nih.gov/pubmed/32748289 http://dx.doi.org/10.1007/s00395-020-0815-1 |