Modified Vaccinia Ankara–Vectored Vaccine Expressing Nucleoprotein and Matrix Protein 1 (M1) Activates Mucosal M1-Specific T-Cell Immunity and Tissue-Resident Memory T Cells in Human Nasopharynx-Associated Lymphoid Tissue

BACKGROUND: Increasing evidence supports a critical role of CD8(+) T-cell immunity against influenza. Activation of mucosal CD8(+) T cells, particularly tissue-resident memory T (T(RM)) cells recognizing conserved epitopes would mediate rapid and broad protection. Matrix protein 1 (M1) is a well-con...

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Detalles Bibliográficos
Autores principales: Puksuriwong, Suttida, Ahmed, Muhammad S, Sharma, Ravi, Krishnan, Madhan, Leong, Sam, Lambe, Teresa, McNamara, Paul S, Gilbert, Sarah C, Zhang, Qibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399703/
https://www.ncbi.nlm.nih.gov/pubmed/31740938
http://dx.doi.org/10.1093/infdis/jiz593

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