Cargando…

Carbohydrate Intake in Early Childhood and Body Composition and Metabolic Health: Results from the Generation R Study

High sugar intake in childhood has been linked to obesity. However, the role of macronutrient substitutions and associations with metabolic health remain unclear. We examined associations of carbohydrate intake and its subtypes with body composition and metabolic health among 3573 children participa...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Anh N., Santos, Susana, Braun, Kim V. E., Voortman, Trudy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399886/
https://www.ncbi.nlm.nih.gov/pubmed/32629760
http://dx.doi.org/10.3390/nu12071940
_version_ 1783566235911323648
author Nguyen, Anh N.
Santos, Susana
Braun, Kim V. E.
Voortman, Trudy
author_facet Nguyen, Anh N.
Santos, Susana
Braun, Kim V. E.
Voortman, Trudy
author_sort Nguyen, Anh N.
collection PubMed
description High sugar intake in childhood has been linked to obesity. However, the role of macronutrient substitutions and associations with metabolic health remain unclear. We examined associations of carbohydrate intake and its subtypes with body composition and metabolic health among 3573 children participating in a population-based cohort in the Netherlands. Intake of total carbohydrate, monosaccharides and disaccharides, and polysaccharides at age 1 year was assessed with a food-frequency questionnaire. We repeatedly measured children’s height and weight to calculate BMI between their ages of 1 and 10 years. At ages 6 and 10 years, fat and fat-free mass were measured with dual-energy X-ray-absorptiometry and blood concentrations of triglycerides, cholesterol, and insulin were obtained. For all outcomes, we calculated age and sexspecific SD-scores. In multivariable-adjusted linear mixed models, we found no associations of intake of carbohydrates or its subtypes with children’s BMI or body composition. A higher intake of monosaccharides and disaccharides was associated with higher triglyceride concentrations (0.02 SDS per 10 g/day, 95% CI: 0.01, 0.04). Higher monosaccharide and disaccharide intake was also associated with lower HDL-cholesterol (−0.03 SDS, 95% CI: −0.04; −0.01), especially when it replaced polysaccharides. Overall, our findings suggest associations of higher monosaccharide and disaccharide intake in early childhood with higher triglyceride and lower HDL-cholesterol concentrations, but do not support associations with body composition.
format Online
Article
Text
id pubmed-7399886
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-73998862020-08-17 Carbohydrate Intake in Early Childhood and Body Composition and Metabolic Health: Results from the Generation R Study Nguyen, Anh N. Santos, Susana Braun, Kim V. E. Voortman, Trudy Nutrients Article High sugar intake in childhood has been linked to obesity. However, the role of macronutrient substitutions and associations with metabolic health remain unclear. We examined associations of carbohydrate intake and its subtypes with body composition and metabolic health among 3573 children participating in a population-based cohort in the Netherlands. Intake of total carbohydrate, monosaccharides and disaccharides, and polysaccharides at age 1 year was assessed with a food-frequency questionnaire. We repeatedly measured children’s height and weight to calculate BMI between their ages of 1 and 10 years. At ages 6 and 10 years, fat and fat-free mass were measured with dual-energy X-ray-absorptiometry and blood concentrations of triglycerides, cholesterol, and insulin were obtained. For all outcomes, we calculated age and sexspecific SD-scores. In multivariable-adjusted linear mixed models, we found no associations of intake of carbohydrates or its subtypes with children’s BMI or body composition. A higher intake of monosaccharides and disaccharides was associated with higher triglyceride concentrations (0.02 SDS per 10 g/day, 95% CI: 0.01, 0.04). Higher monosaccharide and disaccharide intake was also associated with lower HDL-cholesterol (−0.03 SDS, 95% CI: −0.04; −0.01), especially when it replaced polysaccharides. Overall, our findings suggest associations of higher monosaccharide and disaccharide intake in early childhood with higher triglyceride and lower HDL-cholesterol concentrations, but do not support associations with body composition. MDPI 2020-06-30 /pmc/articles/PMC7399886/ /pubmed/32629760 http://dx.doi.org/10.3390/nu12071940 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nguyen, Anh N.
Santos, Susana
Braun, Kim V. E.
Voortman, Trudy
Carbohydrate Intake in Early Childhood and Body Composition and Metabolic Health: Results from the Generation R Study
title Carbohydrate Intake in Early Childhood and Body Composition and Metabolic Health: Results from the Generation R Study
title_full Carbohydrate Intake in Early Childhood and Body Composition and Metabolic Health: Results from the Generation R Study
title_fullStr Carbohydrate Intake in Early Childhood and Body Composition and Metabolic Health: Results from the Generation R Study
title_full_unstemmed Carbohydrate Intake in Early Childhood and Body Composition and Metabolic Health: Results from the Generation R Study
title_short Carbohydrate Intake in Early Childhood and Body Composition and Metabolic Health: Results from the Generation R Study
title_sort carbohydrate intake in early childhood and body composition and metabolic health: results from the generation r study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399886/
https://www.ncbi.nlm.nih.gov/pubmed/32629760
http://dx.doi.org/10.3390/nu12071940
work_keys_str_mv AT nguyenanhn carbohydrateintakeinearlychildhoodandbodycompositionandmetabolichealthresultsfromthegenerationrstudy
AT santossusana carbohydrateintakeinearlychildhoodandbodycompositionandmetabolichealthresultsfromthegenerationrstudy
AT braunkimve carbohydrateintakeinearlychildhoodandbodycompositionandmetabolichealthresultsfromthegenerationrstudy
AT voortmantrudy carbohydrateintakeinearlychildhoodandbodycompositionandmetabolichealthresultsfromthegenerationrstudy