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Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis
Optical coherence tomography (OCT) supports the detection of thickness changes in intraretinal layers at an early stage of diabetes mellitus. However, the analysis of OCT data in cross-sectional studies is complex and time-consuming. We introduce an enhanced deviation map-based analysis (MA) and dem...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399905/ https://www.ncbi.nlm.nih.gov/pubmed/32630622 http://dx.doi.org/10.3390/biomedicines8070190 |
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author | Prakasam, Ruby Kala Matuszewska-Iwanicka, Aleksandra Fischer, Dagmar-Christiane Schumann, Heidrun Tschöpe, Diethelm Stratmann, Bernd Hettlich, Hans-Joachim Guthoff, Rudolf F. Stachs, Oliver Röhlig, Martin |
author_facet | Prakasam, Ruby Kala Matuszewska-Iwanicka, Aleksandra Fischer, Dagmar-Christiane Schumann, Heidrun Tschöpe, Diethelm Stratmann, Bernd Hettlich, Hans-Joachim Guthoff, Rudolf F. Stachs, Oliver Röhlig, Martin |
author_sort | Prakasam, Ruby Kala |
collection | PubMed |
description | Optical coherence tomography (OCT) supports the detection of thickness changes in intraretinal layers at an early stage of diabetes mellitus. However, the analysis of OCT data in cross-sectional studies is complex and time-consuming. We introduce an enhanced deviation map-based analysis (MA) and demonstrate its effectiveness in detecting early changes in intraretinal layer thickness in adults with type 2 diabetes mellitus (T2DM) compared to common early treatment diabetic retinopathy study (ETDRS) grid-based analysis (GA). To this end, we obtained OCT scans of unilateral eyes from 33 T2DM patients without diabetic retinopathy and 40 healthy controls. The patients were categorized according to concomitant diabetic peripheral neuropathy (DN). The results of MA and GA demonstrated statistically significant differences in retinal thickness between patients and controls. Thinning was most pronounced in total retinal thickness and the thickness of the inner retinal layers in areas of the inner macular ring, selectively extending into areas of the outer macular ring and foveal center. Patients with clinically proven DN showed the strongest thinning of the inner retinal layers. MA showed additional areas of thinning whereas GA tended to underestimate thickness changes, especially in areas with localized thinning. We conclude that MA enables a precise analysis of retinal thickness data and contributes to the understanding of localized changes in intraretinal layers in adults with T2DM. |
format | Online Article Text |
id | pubmed-7399905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73999052020-08-17 Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis Prakasam, Ruby Kala Matuszewska-Iwanicka, Aleksandra Fischer, Dagmar-Christiane Schumann, Heidrun Tschöpe, Diethelm Stratmann, Bernd Hettlich, Hans-Joachim Guthoff, Rudolf F. Stachs, Oliver Röhlig, Martin Biomedicines Article Optical coherence tomography (OCT) supports the detection of thickness changes in intraretinal layers at an early stage of diabetes mellitus. However, the analysis of OCT data in cross-sectional studies is complex and time-consuming. We introduce an enhanced deviation map-based analysis (MA) and demonstrate its effectiveness in detecting early changes in intraretinal layer thickness in adults with type 2 diabetes mellitus (T2DM) compared to common early treatment diabetic retinopathy study (ETDRS) grid-based analysis (GA). To this end, we obtained OCT scans of unilateral eyes from 33 T2DM patients without diabetic retinopathy and 40 healthy controls. The patients were categorized according to concomitant diabetic peripheral neuropathy (DN). The results of MA and GA demonstrated statistically significant differences in retinal thickness between patients and controls. Thinning was most pronounced in total retinal thickness and the thickness of the inner retinal layers in areas of the inner macular ring, selectively extending into areas of the outer macular ring and foveal center. Patients with clinically proven DN showed the strongest thinning of the inner retinal layers. MA showed additional areas of thinning whereas GA tended to underestimate thickness changes, especially in areas with localized thinning. We conclude that MA enables a precise analysis of retinal thickness data and contributes to the understanding of localized changes in intraretinal layers in adults with T2DM. MDPI 2020-07-02 /pmc/articles/PMC7399905/ /pubmed/32630622 http://dx.doi.org/10.3390/biomedicines8070190 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Prakasam, Ruby Kala Matuszewska-Iwanicka, Aleksandra Fischer, Dagmar-Christiane Schumann, Heidrun Tschöpe, Diethelm Stratmann, Bernd Hettlich, Hans-Joachim Guthoff, Rudolf F. Stachs, Oliver Röhlig, Martin Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis |
title | Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis |
title_full | Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis |
title_fullStr | Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis |
title_full_unstemmed | Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis |
title_short | Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis |
title_sort | thickness of intraretinal layers in patients with type 2 diabetes mellitus depending on a concomitant diabetic neuropathy: results of a cross-sectional study using deviation maps for oct data analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399905/ https://www.ncbi.nlm.nih.gov/pubmed/32630622 http://dx.doi.org/10.3390/biomedicines8070190 |
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