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Diagnostic Ability of Structural Transcranial Sonography in Patients with Alzheimer’s Disease

The aim of this study was to assess the diagnostic ability of transcranial sonography (TCS) for the evaluation of the medial temporal lobe (MTL) in Alzheimer’s disease (AD). Standard neuropsychological evaluation, TCS and 1.5 T MRI were performed for 20 patients with AD and for 20 age- and sex-match...

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Autores principales: Rastenyte, Daiva, Matijosaitis, Vaidas, Laucius, Ovidijus, Gleizniene, Rymante, Jesmanas, Simonas, Jureniene, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400014/
https://www.ncbi.nlm.nih.gov/pubmed/32664455
http://dx.doi.org/10.3390/diagnostics10070471
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author Rastenyte, Daiva
Matijosaitis, Vaidas
Laucius, Ovidijus
Gleizniene, Rymante
Jesmanas, Simonas
Jureniene, Kristina
author_facet Rastenyte, Daiva
Matijosaitis, Vaidas
Laucius, Ovidijus
Gleizniene, Rymante
Jesmanas, Simonas
Jureniene, Kristina
author_sort Rastenyte, Daiva
collection PubMed
description The aim of this study was to assess the diagnostic ability of transcranial sonography (TCS) for the evaluation of the medial temporal lobe (MTL) in Alzheimer’s disease (AD). Standard neuropsychological evaluation, TCS and 1.5 T MRI were performed for 20 patients with AD and for 20 age- and sex-matched healthy controls in a prospective manner. Measurements of the size of the third ventricle and heights of the MTL (A) and the choroidal fissure (B) were performed twice on each side by two independent neurosonologists for all participants. On MRI, both conventional and volumetric analyses of the third ventricle and hippocampus were performed. Receiver operating characteristic (ROC) curves analyses were applied. Height of the MTL on TCS had sensitivities of 73.7% (right)/63.2%(left) and specificities of 65% (right)/65–70% (left) Area under a curve (AUC) 75.4–77.2% (right), 60.4–67.8% (left)) for AD. A/B ratio on TCS had sensitivities of 73.7% (right)/57.9% (left) and specificities of 70.0% (right)/55.0% (left) (AUC 73.3% (right), 60.4% (left)) by the experienced neurosonologist, and sensitivities of 78.9% (right and left) and specificities of 60.0% (right)/65.0% (left) (AUC 77.8–80.0%) by the inexperienced neurosonologist for AD. On MRI, linear measurement of the hippocampus and parahippocampal gyrus height had sensitivities of 84.2% (right)/89.5% (left) and specificities of 80.0% (right)/85% (left) (AUC 86.1–92.9%) for AD. Hippocampal volume had sensitivities of 70% (right and left) and specificities of 75% (right)/80% (left) (AUC 77.5–78%) for AD. Atrophy of the right MTL in AD could be detected on TCS with a good diagnostic ability, however MRI performed better on the left.
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spelling pubmed-74000142020-08-23 Diagnostic Ability of Structural Transcranial Sonography in Patients with Alzheimer’s Disease Rastenyte, Daiva Matijosaitis, Vaidas Laucius, Ovidijus Gleizniene, Rymante Jesmanas, Simonas Jureniene, Kristina Diagnostics (Basel) Article The aim of this study was to assess the diagnostic ability of transcranial sonography (TCS) for the evaluation of the medial temporal lobe (MTL) in Alzheimer’s disease (AD). Standard neuropsychological evaluation, TCS and 1.5 T MRI were performed for 20 patients with AD and for 20 age- and sex-matched healthy controls in a prospective manner. Measurements of the size of the third ventricle and heights of the MTL (A) and the choroidal fissure (B) were performed twice on each side by two independent neurosonologists for all participants. On MRI, both conventional and volumetric analyses of the third ventricle and hippocampus were performed. Receiver operating characteristic (ROC) curves analyses were applied. Height of the MTL on TCS had sensitivities of 73.7% (right)/63.2%(left) and specificities of 65% (right)/65–70% (left) Area under a curve (AUC) 75.4–77.2% (right), 60.4–67.8% (left)) for AD. A/B ratio on TCS had sensitivities of 73.7% (right)/57.9% (left) and specificities of 70.0% (right)/55.0% (left) (AUC 73.3% (right), 60.4% (left)) by the experienced neurosonologist, and sensitivities of 78.9% (right and left) and specificities of 60.0% (right)/65.0% (left) (AUC 77.8–80.0%) by the inexperienced neurosonologist for AD. On MRI, linear measurement of the hippocampus and parahippocampal gyrus height had sensitivities of 84.2% (right)/89.5% (left) and specificities of 80.0% (right)/85% (left) (AUC 86.1–92.9%) for AD. Hippocampal volume had sensitivities of 70% (right and left) and specificities of 75% (right)/80% (left) (AUC 77.5–78%) for AD. Atrophy of the right MTL in AD could be detected on TCS with a good diagnostic ability, however MRI performed better on the left. MDPI 2020-07-10 /pmc/articles/PMC7400014/ /pubmed/32664455 http://dx.doi.org/10.3390/diagnostics10070471 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rastenyte, Daiva
Matijosaitis, Vaidas
Laucius, Ovidijus
Gleizniene, Rymante
Jesmanas, Simonas
Jureniene, Kristina
Diagnostic Ability of Structural Transcranial Sonography in Patients with Alzheimer’s Disease
title Diagnostic Ability of Structural Transcranial Sonography in Patients with Alzheimer’s Disease
title_full Diagnostic Ability of Structural Transcranial Sonography in Patients with Alzheimer’s Disease
title_fullStr Diagnostic Ability of Structural Transcranial Sonography in Patients with Alzheimer’s Disease
title_full_unstemmed Diagnostic Ability of Structural Transcranial Sonography in Patients with Alzheimer’s Disease
title_short Diagnostic Ability of Structural Transcranial Sonography in Patients with Alzheimer’s Disease
title_sort diagnostic ability of structural transcranial sonography in patients with alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400014/
https://www.ncbi.nlm.nih.gov/pubmed/32664455
http://dx.doi.org/10.3390/diagnostics10070471
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