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Acute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution

Glucagon-like peptide-1 receptor agonists induce weight loss, which has been suggested to relate to the slowing of gastric emptying (GE). In health, energy intake (EI) is more strongly related to the content of the distal, than the total, stomach. We evaluated the effects of lixisenatide on GE, intr...

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Autores principales: Jalleh, Ryan, Pham, Hung, Marathe, Chinmay S., Wu, Tongzhi, Buttfield, Madeline D., Hatzinikolas, Seva, Malbert, Charles H., Rigda, Rachael S., Lange, Kylie, Trahair, Laurence G., Feinle-Bisset, Christine, Rayner, Christopher K., Horowitz, Michael, Jones, Karen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400134/
https://www.ncbi.nlm.nih.gov/pubmed/32630191
http://dx.doi.org/10.3390/nu12071962
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author Jalleh, Ryan
Pham, Hung
Marathe, Chinmay S.
Wu, Tongzhi
Buttfield, Madeline D.
Hatzinikolas, Seva
Malbert, Charles H.
Rigda, Rachael S.
Lange, Kylie
Trahair, Laurence G.
Feinle-Bisset, Christine
Rayner, Christopher K.
Horowitz, Michael
Jones, Karen L.
author_facet Jalleh, Ryan
Pham, Hung
Marathe, Chinmay S.
Wu, Tongzhi
Buttfield, Madeline D.
Hatzinikolas, Seva
Malbert, Charles H.
Rigda, Rachael S.
Lange, Kylie
Trahair, Laurence G.
Feinle-Bisset, Christine
Rayner, Christopher K.
Horowitz, Michael
Jones, Karen L.
author_sort Jalleh, Ryan
collection PubMed
description Glucagon-like peptide-1 receptor agonists induce weight loss, which has been suggested to relate to the slowing of gastric emptying (GE). In health, energy intake (EI) is more strongly related to the content of the distal, than the total, stomach. We evaluated the effects of lixisenatide on GE, intragastric distribution, and subsequent EI in 15 healthy participants and 15 patients with type 2 diabetes (T2D). Participants ingested a 75-g glucose drink on two separate occasions, 30 min after lixisenatide (10 mcg) or placebo subcutaneously, in a randomised, double-blind, crossover design. GE and intragastric distribution were measured for 180 min followed by a buffet-style meal, where EI was quantified. Relationships of EI with total, proximal, and distal stomach content were assessed. In both groups, lixisenatide slowed GE markedly, with increased retention in both the proximal (p < 0.001) and distal (p < 0.001) stomach and decreased EI (p < 0.001). EI was not related to the content of the total or proximal stomach but inversely related to the distal stomach at 180 min in health on placebo (r = −0.58, p = 0.03) but not in T2D nor after lixisenatide in either group. In healthy and T2D participants, the reduction in EI by lixisenatide is unrelated to changes in GE/intragastric distribution, consistent with a centrally mediated effect.
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spelling pubmed-74001342020-08-23 Acute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution Jalleh, Ryan Pham, Hung Marathe, Chinmay S. Wu, Tongzhi Buttfield, Madeline D. Hatzinikolas, Seva Malbert, Charles H. Rigda, Rachael S. Lange, Kylie Trahair, Laurence G. Feinle-Bisset, Christine Rayner, Christopher K. Horowitz, Michael Jones, Karen L. Nutrients Article Glucagon-like peptide-1 receptor agonists induce weight loss, which has been suggested to relate to the slowing of gastric emptying (GE). In health, energy intake (EI) is more strongly related to the content of the distal, than the total, stomach. We evaluated the effects of lixisenatide on GE, intragastric distribution, and subsequent EI in 15 healthy participants and 15 patients with type 2 diabetes (T2D). Participants ingested a 75-g glucose drink on two separate occasions, 30 min after lixisenatide (10 mcg) or placebo subcutaneously, in a randomised, double-blind, crossover design. GE and intragastric distribution were measured for 180 min followed by a buffet-style meal, where EI was quantified. Relationships of EI with total, proximal, and distal stomach content were assessed. In both groups, lixisenatide slowed GE markedly, with increased retention in both the proximal (p < 0.001) and distal (p < 0.001) stomach and decreased EI (p < 0.001). EI was not related to the content of the total or proximal stomach but inversely related to the distal stomach at 180 min in health on placebo (r = −0.58, p = 0.03) but not in T2D nor after lixisenatide in either group. In healthy and T2D participants, the reduction in EI by lixisenatide is unrelated to changes in GE/intragastric distribution, consistent with a centrally mediated effect. MDPI 2020-07-01 /pmc/articles/PMC7400134/ /pubmed/32630191 http://dx.doi.org/10.3390/nu12071962 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jalleh, Ryan
Pham, Hung
Marathe, Chinmay S.
Wu, Tongzhi
Buttfield, Madeline D.
Hatzinikolas, Seva
Malbert, Charles H.
Rigda, Rachael S.
Lange, Kylie
Trahair, Laurence G.
Feinle-Bisset, Christine
Rayner, Christopher K.
Horowitz, Michael
Jones, Karen L.
Acute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution
title Acute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution
title_full Acute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution
title_fullStr Acute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution
title_full_unstemmed Acute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution
title_short Acute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution
title_sort acute effects of lixisenatide on energy intake in healthy subjects and patients with type 2 diabetes: relationship to gastric emptying and intragastric distribution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400134/
https://www.ncbi.nlm.nih.gov/pubmed/32630191
http://dx.doi.org/10.3390/nu12071962
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