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Serum γ-Glutamyltransferase Concentration Predicts Endothelial Dysfunction in Naïve Hypertensive Patients

Background: Serum gamma-glutamyltransferase (γ-GT) is recognized as a risk factor for cardiovascular diseases (CV). Traditional cardiovascular risk factors mediate endothelial dysfunction. Aim: to evaluate a possible correlation between serum γ-GT and endothelium-dependent vasodilation in naïve hype...

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Autores principales: Perticone, Maria, Maio, Raffaele, Caroleo, Benedetto, Sciacqua, Angela, Suraci, Edoardo, Gigliotti, Simona, Martino, Francesco, Andreozzi, Francesco, Sesti, Giorgio, Perticone, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400291/
https://www.ncbi.nlm.nih.gov/pubmed/32664562
http://dx.doi.org/10.3390/biomedicines8070207
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author Perticone, Maria
Maio, Raffaele
Caroleo, Benedetto
Sciacqua, Angela
Suraci, Edoardo
Gigliotti, Simona
Martino, Francesco
Andreozzi, Francesco
Sesti, Giorgio
Perticone, Francesco
author_facet Perticone, Maria
Maio, Raffaele
Caroleo, Benedetto
Sciacqua, Angela
Suraci, Edoardo
Gigliotti, Simona
Martino, Francesco
Andreozzi, Francesco
Sesti, Giorgio
Perticone, Francesco
author_sort Perticone, Maria
collection PubMed
description Background: Serum gamma-glutamyltransferase (γ-GT) is recognized as a risk factor for cardiovascular diseases (CV). Traditional cardiovascular risk factors mediate endothelial dysfunction. Aim: to evaluate a possible correlation between serum γ-GT and endothelium-dependent vasodilation in naïve hypertensives. Methods: We enrolled 500 hypertensives. Endothelial function was studied by strain-gauge plethysmography. Receiver operating characteristic (ROC) analysis was used to assess the predictive value of γ-GT and to identify the optimal cut-off value of the same variable for endothelial dysfunction. Results: At univariate linear analysis peak percent increase in acetylcholine (ACh)-stimulated vasodilation was inversely related to γ-GT (r = −0.587), alanine aminotransferase (ALT) (r = −0.559), aspartate aminotransferase (AST) (r = −0.464), age (r = −0.171), body mass index (BMI) (r = −0.152), and fasting glucose (r = −101). In the stepwise multivariate regression model, endothelium-dependent vasodilation was significantly related to γ-GT (β = −0.362), ALT (β = −0.297), AST (β = −0.217), estimated glomerular filtration rate (e-GFR) (β = 0.199), gender (β = 0.166), and smoking (β = −0.061). The ROC analysis demonstrated that the accuracy of γ-GT for identifying patients with endothelial dysfunction was 82.1%; the optimal γ-GT cut-off value for discriminating patients with this alteration was 27 UI/L. Conclusions: Serum γ-GT values, within the normal range, are significantly associated with endothelial dysfunction in hypertensives, and may be considered a biomarker of early vascular damage.
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spelling pubmed-74002912020-08-23 Serum γ-Glutamyltransferase Concentration Predicts Endothelial Dysfunction in Naïve Hypertensive Patients Perticone, Maria Maio, Raffaele Caroleo, Benedetto Sciacqua, Angela Suraci, Edoardo Gigliotti, Simona Martino, Francesco Andreozzi, Francesco Sesti, Giorgio Perticone, Francesco Biomedicines Article Background: Serum gamma-glutamyltransferase (γ-GT) is recognized as a risk factor for cardiovascular diseases (CV). Traditional cardiovascular risk factors mediate endothelial dysfunction. Aim: to evaluate a possible correlation between serum γ-GT and endothelium-dependent vasodilation in naïve hypertensives. Methods: We enrolled 500 hypertensives. Endothelial function was studied by strain-gauge plethysmography. Receiver operating characteristic (ROC) analysis was used to assess the predictive value of γ-GT and to identify the optimal cut-off value of the same variable for endothelial dysfunction. Results: At univariate linear analysis peak percent increase in acetylcholine (ACh)-stimulated vasodilation was inversely related to γ-GT (r = −0.587), alanine aminotransferase (ALT) (r = −0.559), aspartate aminotransferase (AST) (r = −0.464), age (r = −0.171), body mass index (BMI) (r = −0.152), and fasting glucose (r = −101). In the stepwise multivariate regression model, endothelium-dependent vasodilation was significantly related to γ-GT (β = −0.362), ALT (β = −0.297), AST (β = −0.217), estimated glomerular filtration rate (e-GFR) (β = 0.199), gender (β = 0.166), and smoking (β = −0.061). The ROC analysis demonstrated that the accuracy of γ-GT for identifying patients with endothelial dysfunction was 82.1%; the optimal γ-GT cut-off value for discriminating patients with this alteration was 27 UI/L. Conclusions: Serum γ-GT values, within the normal range, are significantly associated with endothelial dysfunction in hypertensives, and may be considered a biomarker of early vascular damage. MDPI 2020-07-11 /pmc/articles/PMC7400291/ /pubmed/32664562 http://dx.doi.org/10.3390/biomedicines8070207 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Perticone, Maria
Maio, Raffaele
Caroleo, Benedetto
Sciacqua, Angela
Suraci, Edoardo
Gigliotti, Simona
Martino, Francesco
Andreozzi, Francesco
Sesti, Giorgio
Perticone, Francesco
Serum γ-Glutamyltransferase Concentration Predicts Endothelial Dysfunction in Naïve Hypertensive Patients
title Serum γ-Glutamyltransferase Concentration Predicts Endothelial Dysfunction in Naïve Hypertensive Patients
title_full Serum γ-Glutamyltransferase Concentration Predicts Endothelial Dysfunction in Naïve Hypertensive Patients
title_fullStr Serum γ-Glutamyltransferase Concentration Predicts Endothelial Dysfunction in Naïve Hypertensive Patients
title_full_unstemmed Serum γ-Glutamyltransferase Concentration Predicts Endothelial Dysfunction in Naïve Hypertensive Patients
title_short Serum γ-Glutamyltransferase Concentration Predicts Endothelial Dysfunction in Naïve Hypertensive Patients
title_sort serum γ-glutamyltransferase concentration predicts endothelial dysfunction in naïve hypertensive patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400291/
https://www.ncbi.nlm.nih.gov/pubmed/32664562
http://dx.doi.org/10.3390/biomedicines8070207
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