Cargando…
Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients
Background: This study aimed to evaluate and identify the specific CT findings by focusing on abnormalities in the main pancreatic duct (MPD) and pancreatic parenchyma in patients with small pancreatic cancer (PC) including carcinoma in situ (CIS). Methods: Nine CT findings indicating abnormalities...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400308/ https://www.ncbi.nlm.nih.gov/pubmed/32630180 http://dx.doi.org/10.3390/diagnostics10070445 |
_version_ | 1783566333789601792 |
---|---|
author | Yamao, Kentaro Takenaka, Mamoru Ishikawa, Rei Okamoto, Ayana Yamazaki, Tomohiro Nakai, Atsushi Omoto, Shunsuke Kamata, Ken Minaga, Kosuke Matsumoto, Ippei Takeyama, Yoshifumi Numoto, Isao Tsurusaki, Masakatsu Chikugo, Takaaki Chiba, Yasutaka Watanabe, Tomohiro Kudo, Masatoshi |
author_facet | Yamao, Kentaro Takenaka, Mamoru Ishikawa, Rei Okamoto, Ayana Yamazaki, Tomohiro Nakai, Atsushi Omoto, Shunsuke Kamata, Ken Minaga, Kosuke Matsumoto, Ippei Takeyama, Yoshifumi Numoto, Isao Tsurusaki, Masakatsu Chikugo, Takaaki Chiba, Yasutaka Watanabe, Tomohiro Kudo, Masatoshi |
author_sort | Yamao, Kentaro |
collection | PubMed |
description | Background: This study aimed to evaluate and identify the specific CT findings by focusing on abnormalities in the main pancreatic duct (MPD) and pancreatic parenchyma in patients with small pancreatic cancer (PC) including carcinoma in situ (CIS). Methods: Nine CT findings indicating abnormalities of MPD and pancreatic parenchyma were selected as candidate findings for the presence of small PC ≤ 10 mm. The proportions of patients positive for each finding were compared between small PC and benign MPD stenosis groups. Interobserver agreement between two independent image reviewers was evaluated using kappa statistics. Results: The final analysis included 24 patients with small PC (including 11 CIS patients) and 28 patients with benign MPD stenosis. The proportion of patients exhibiting partial pancreatic parenchymal atrophy (PPA) corresponding to the distribution of MPD stenosis (45.8% vs. 7.1%, p < 0.01), upstream PPA arising from the site of MPD stenosis (33.3% vs. 3.6%, p = 0.01), and MPD abrupt stenosis (45.8% vs. 14.3%, p = 0.03) was significantly higher in the small PC group than in the benign MPD stenosis group. Conclusions: The presence of partial PPA, upstream PPA, and MPD abrupt stenosis on a CT image was highly suggestive of the presence of small PCs including CIS. |
format | Online Article Text |
id | pubmed-7400308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74003082020-08-23 Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients Yamao, Kentaro Takenaka, Mamoru Ishikawa, Rei Okamoto, Ayana Yamazaki, Tomohiro Nakai, Atsushi Omoto, Shunsuke Kamata, Ken Minaga, Kosuke Matsumoto, Ippei Takeyama, Yoshifumi Numoto, Isao Tsurusaki, Masakatsu Chikugo, Takaaki Chiba, Yasutaka Watanabe, Tomohiro Kudo, Masatoshi Diagnostics (Basel) Article Background: This study aimed to evaluate and identify the specific CT findings by focusing on abnormalities in the main pancreatic duct (MPD) and pancreatic parenchyma in patients with small pancreatic cancer (PC) including carcinoma in situ (CIS). Methods: Nine CT findings indicating abnormalities of MPD and pancreatic parenchyma were selected as candidate findings for the presence of small PC ≤ 10 mm. The proportions of patients positive for each finding were compared between small PC and benign MPD stenosis groups. Interobserver agreement between two independent image reviewers was evaluated using kappa statistics. Results: The final analysis included 24 patients with small PC (including 11 CIS patients) and 28 patients with benign MPD stenosis. The proportion of patients exhibiting partial pancreatic parenchymal atrophy (PPA) corresponding to the distribution of MPD stenosis (45.8% vs. 7.1%, p < 0.01), upstream PPA arising from the site of MPD stenosis (33.3% vs. 3.6%, p = 0.01), and MPD abrupt stenosis (45.8% vs. 14.3%, p = 0.03) was significantly higher in the small PC group than in the benign MPD stenosis group. Conclusions: The presence of partial PPA, upstream PPA, and MPD abrupt stenosis on a CT image was highly suggestive of the presence of small PCs including CIS. MDPI 2020-07-01 /pmc/articles/PMC7400308/ /pubmed/32630180 http://dx.doi.org/10.3390/diagnostics10070445 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yamao, Kentaro Takenaka, Mamoru Ishikawa, Rei Okamoto, Ayana Yamazaki, Tomohiro Nakai, Atsushi Omoto, Shunsuke Kamata, Ken Minaga, Kosuke Matsumoto, Ippei Takeyama, Yoshifumi Numoto, Isao Tsurusaki, Masakatsu Chikugo, Takaaki Chiba, Yasutaka Watanabe, Tomohiro Kudo, Masatoshi Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients |
title | Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients |
title_full | Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients |
title_fullStr | Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients |
title_full_unstemmed | Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients |
title_short | Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients |
title_sort | partial pancreatic parenchymal atrophy is a new specific finding to diagnose small pancreatic cancer (≤10 mm) including carcinoma in situ: comparison with localized benign main pancreatic duct stenosis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400308/ https://www.ncbi.nlm.nih.gov/pubmed/32630180 http://dx.doi.org/10.3390/diagnostics10070445 |
work_keys_str_mv | AT yamaokentaro partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT takenakamamoru partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT ishikawarei partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT okamotoayana partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT yamazakitomohiro partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT nakaiatsushi partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT omotoshunsuke partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT kamataken partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT minagakosuke partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT matsumotoippei partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT takeyamayoshifumi partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT numotoisao partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT tsurusakimasakatsu partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT chikugotakaaki partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT chibayasutaka partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT watanabetomohiro partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients AT kudomasatoshi partialpancreaticparenchymalatrophyisanewspecificfindingtodiagnosesmallpancreaticcancer10mmincludingcarcinomainsitucomparisonwithlocalizedbenignmainpancreaticductstenosispatients |