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Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients

Background: This study aimed to evaluate and identify the specific CT findings by focusing on abnormalities in the main pancreatic duct (MPD) and pancreatic parenchyma in patients with small pancreatic cancer (PC) including carcinoma in situ (CIS). Methods: Nine CT findings indicating abnormalities...

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Autores principales: Yamao, Kentaro, Takenaka, Mamoru, Ishikawa, Rei, Okamoto, Ayana, Yamazaki, Tomohiro, Nakai, Atsushi, Omoto, Shunsuke, Kamata, Ken, Minaga, Kosuke, Matsumoto, Ippei, Takeyama, Yoshifumi, Numoto, Isao, Tsurusaki, Masakatsu, Chikugo, Takaaki, Chiba, Yasutaka, Watanabe, Tomohiro, Kudo, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400308/
https://www.ncbi.nlm.nih.gov/pubmed/32630180
http://dx.doi.org/10.3390/diagnostics10070445
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author Yamao, Kentaro
Takenaka, Mamoru
Ishikawa, Rei
Okamoto, Ayana
Yamazaki, Tomohiro
Nakai, Atsushi
Omoto, Shunsuke
Kamata, Ken
Minaga, Kosuke
Matsumoto, Ippei
Takeyama, Yoshifumi
Numoto, Isao
Tsurusaki, Masakatsu
Chikugo, Takaaki
Chiba, Yasutaka
Watanabe, Tomohiro
Kudo, Masatoshi
author_facet Yamao, Kentaro
Takenaka, Mamoru
Ishikawa, Rei
Okamoto, Ayana
Yamazaki, Tomohiro
Nakai, Atsushi
Omoto, Shunsuke
Kamata, Ken
Minaga, Kosuke
Matsumoto, Ippei
Takeyama, Yoshifumi
Numoto, Isao
Tsurusaki, Masakatsu
Chikugo, Takaaki
Chiba, Yasutaka
Watanabe, Tomohiro
Kudo, Masatoshi
author_sort Yamao, Kentaro
collection PubMed
description Background: This study aimed to evaluate and identify the specific CT findings by focusing on abnormalities in the main pancreatic duct (MPD) and pancreatic parenchyma in patients with small pancreatic cancer (PC) including carcinoma in situ (CIS). Methods: Nine CT findings indicating abnormalities of MPD and pancreatic parenchyma were selected as candidate findings for the presence of small PC ≤ 10 mm. The proportions of patients positive for each finding were compared between small PC and benign MPD stenosis groups. Interobserver agreement between two independent image reviewers was evaluated using kappa statistics. Results: The final analysis included 24 patients with small PC (including 11 CIS patients) and 28 patients with benign MPD stenosis. The proportion of patients exhibiting partial pancreatic parenchymal atrophy (PPA) corresponding to the distribution of MPD stenosis (45.8% vs. 7.1%, p < 0.01), upstream PPA arising from the site of MPD stenosis (33.3% vs. 3.6%, p = 0.01), and MPD abrupt stenosis (45.8% vs. 14.3%, p = 0.03) was significantly higher in the small PC group than in the benign MPD stenosis group. Conclusions: The presence of partial PPA, upstream PPA, and MPD abrupt stenosis on a CT image was highly suggestive of the presence of small PCs including CIS.
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spelling pubmed-74003082020-08-23 Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients Yamao, Kentaro Takenaka, Mamoru Ishikawa, Rei Okamoto, Ayana Yamazaki, Tomohiro Nakai, Atsushi Omoto, Shunsuke Kamata, Ken Minaga, Kosuke Matsumoto, Ippei Takeyama, Yoshifumi Numoto, Isao Tsurusaki, Masakatsu Chikugo, Takaaki Chiba, Yasutaka Watanabe, Tomohiro Kudo, Masatoshi Diagnostics (Basel) Article Background: This study aimed to evaluate and identify the specific CT findings by focusing on abnormalities in the main pancreatic duct (MPD) and pancreatic parenchyma in patients with small pancreatic cancer (PC) including carcinoma in situ (CIS). Methods: Nine CT findings indicating abnormalities of MPD and pancreatic parenchyma were selected as candidate findings for the presence of small PC ≤ 10 mm. The proportions of patients positive for each finding were compared between small PC and benign MPD stenosis groups. Interobserver agreement between two independent image reviewers was evaluated using kappa statistics. Results: The final analysis included 24 patients with small PC (including 11 CIS patients) and 28 patients with benign MPD stenosis. The proportion of patients exhibiting partial pancreatic parenchymal atrophy (PPA) corresponding to the distribution of MPD stenosis (45.8% vs. 7.1%, p < 0.01), upstream PPA arising from the site of MPD stenosis (33.3% vs. 3.6%, p = 0.01), and MPD abrupt stenosis (45.8% vs. 14.3%, p = 0.03) was significantly higher in the small PC group than in the benign MPD stenosis group. Conclusions: The presence of partial PPA, upstream PPA, and MPD abrupt stenosis on a CT image was highly suggestive of the presence of small PCs including CIS. MDPI 2020-07-01 /pmc/articles/PMC7400308/ /pubmed/32630180 http://dx.doi.org/10.3390/diagnostics10070445 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yamao, Kentaro
Takenaka, Mamoru
Ishikawa, Rei
Okamoto, Ayana
Yamazaki, Tomohiro
Nakai, Atsushi
Omoto, Shunsuke
Kamata, Ken
Minaga, Kosuke
Matsumoto, Ippei
Takeyama, Yoshifumi
Numoto, Isao
Tsurusaki, Masakatsu
Chikugo, Takaaki
Chiba, Yasutaka
Watanabe, Tomohiro
Kudo, Masatoshi
Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients
title Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients
title_full Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients
title_fullStr Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients
title_full_unstemmed Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients
title_short Partial Pancreatic Parenchymal Atrophy Is a New Specific Finding to Diagnose Small Pancreatic Cancer (≤10 mm) Including Carcinoma in Situ: Comparison with Localized Benign Main Pancreatic Duct Stenosis Patients
title_sort partial pancreatic parenchymal atrophy is a new specific finding to diagnose small pancreatic cancer (≤10 mm) including carcinoma in situ: comparison with localized benign main pancreatic duct stenosis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400308/
https://www.ncbi.nlm.nih.gov/pubmed/32630180
http://dx.doi.org/10.3390/diagnostics10070445
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