Cargando…

The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Patients: A Randomized Controlled Trial

The combination of exercise and nutritional intervention is widely used for stroke patients, as well as frail or sarcopenic older persons. As previously shown, supplemental branched chain amino acids (BCAAs) or protein to gain muscle mass has usually been given just after exercise. This study invest...

Descripción completa

Detalles Bibliográficos
Autores principales: Ikeda, Takashi, Morotomi, Nobuo, Kamono, Arinori, Ishimoto, Saki, Miyazawa, Ryo, Kometani, Shogo, Sako, Rikitaro, Kaneko, Naohisa, Iida, Mamoru, Kawate, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400340/
https://www.ncbi.nlm.nih.gov/pubmed/32610608
http://dx.doi.org/10.3390/nu12071928
_version_ 1783566341330960384
author Ikeda, Takashi
Morotomi, Nobuo
Kamono, Arinori
Ishimoto, Saki
Miyazawa, Ryo
Kometani, Shogo
Sako, Rikitaro
Kaneko, Naohisa
Iida, Mamoru
Kawate, Nobuyuki
author_facet Ikeda, Takashi
Morotomi, Nobuo
Kamono, Arinori
Ishimoto, Saki
Miyazawa, Ryo
Kometani, Shogo
Sako, Rikitaro
Kaneko, Naohisa
Iida, Mamoru
Kawate, Nobuyuki
author_sort Ikeda, Takashi
collection PubMed
description The combination of exercise and nutritional intervention is widely used for stroke patients, as well as frail or sarcopenic older persons. As previously shown, supplemental branched chain amino acids (BCAAs) or protein to gain muscle mass has usually been given just after exercise. This study investigated the effect of the timing of supplemental BCAAs with exercise intervention on physical function in stroke patients. The participants were randomly assigned to two groups based on the timing of supplementation: breakfast (n = 23) and post-exercise (n = 23). The supplement in the breakfast group was provided at 08:00 with breakfast, and in the post-exercise group it was provided just after the exercise session in the afternoon at 14:00–18:00. In both groups, the exercise intervention was performed with two sessions a day for two months. The main effects were observed in body fat mass (p = 0.02, confidence interval (CI): 13.2–17.7), leg press strength (p = 0.04, CI: 94.5–124.5), and Berg balance scale (p = 0.03, CI: 41.6–52.6), but no interaction with intake timing was observed. Although the effect of the timing of supplementation on skeletal muscle mass was similar in both groups, BCAA intake with breakfast was effective for improving physical performance and decreasing body fat mass. The results suggest that a combination of BCAA intake with breakfast and an exercise program was effective for promoting rehabilitation of post-stroke patients.
format Online
Article
Text
id pubmed-7400340
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74003402020-08-23 The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Patients: A Randomized Controlled Trial Ikeda, Takashi Morotomi, Nobuo Kamono, Arinori Ishimoto, Saki Miyazawa, Ryo Kometani, Shogo Sako, Rikitaro Kaneko, Naohisa Iida, Mamoru Kawate, Nobuyuki Nutrients Article The combination of exercise and nutritional intervention is widely used for stroke patients, as well as frail or sarcopenic older persons. As previously shown, supplemental branched chain amino acids (BCAAs) or protein to gain muscle mass has usually been given just after exercise. This study investigated the effect of the timing of supplemental BCAAs with exercise intervention on physical function in stroke patients. The participants were randomly assigned to two groups based on the timing of supplementation: breakfast (n = 23) and post-exercise (n = 23). The supplement in the breakfast group was provided at 08:00 with breakfast, and in the post-exercise group it was provided just after the exercise session in the afternoon at 14:00–18:00. In both groups, the exercise intervention was performed with two sessions a day for two months. The main effects were observed in body fat mass (p = 0.02, confidence interval (CI): 13.2–17.7), leg press strength (p = 0.04, CI: 94.5–124.5), and Berg balance scale (p = 0.03, CI: 41.6–52.6), but no interaction with intake timing was observed. Although the effect of the timing of supplementation on skeletal muscle mass was similar in both groups, BCAA intake with breakfast was effective for improving physical performance and decreasing body fat mass. The results suggest that a combination of BCAA intake with breakfast and an exercise program was effective for promoting rehabilitation of post-stroke patients. MDPI 2020-06-29 /pmc/articles/PMC7400340/ /pubmed/32610608 http://dx.doi.org/10.3390/nu12071928 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ikeda, Takashi
Morotomi, Nobuo
Kamono, Arinori
Ishimoto, Saki
Miyazawa, Ryo
Kometani, Shogo
Sako, Rikitaro
Kaneko, Naohisa
Iida, Mamoru
Kawate, Nobuyuki
The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Patients: A Randomized Controlled Trial
title The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Patients: A Randomized Controlled Trial
title_full The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Patients: A Randomized Controlled Trial
title_fullStr The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Patients: A Randomized Controlled Trial
title_full_unstemmed The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Patients: A Randomized Controlled Trial
title_short The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Patients: A Randomized Controlled Trial
title_sort effects of timing of a leucine-enriched amino acid supplement on body composition and physical function in stroke patients: a randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400340/
https://www.ncbi.nlm.nih.gov/pubmed/32610608
http://dx.doi.org/10.3390/nu12071928
work_keys_str_mv AT ikedatakashi theeffectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT morotominobuo theeffectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT kamonoarinori theeffectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT ishimotosaki theeffectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT miyazawaryo theeffectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT kometanishogo theeffectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT sakorikitaro theeffectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT kanekonaohisa theeffectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT iidamamoru theeffectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT kawatenobuyuki theeffectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT ikedatakashi effectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT morotominobuo effectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT kamonoarinori effectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT ishimotosaki effectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT miyazawaryo effectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT kometanishogo effectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT sakorikitaro effectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT kanekonaohisa effectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT iidamamoru effectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial
AT kawatenobuyuki effectsoftimingofaleucineenrichedaminoacidsupplementonbodycompositionandphysicalfunctioninstrokepatientsarandomizedcontrolledtrial