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Laboratory Diagnosis of Paratyphoid Fever: Opportunity of Surface Plasmon Resonance

Paratyphoid fever is caused by the bacterium Salmonella enterica serovar Paratyphi (A, B and C), and contributes significantly to global disease burden. One of the major challenges in the diagnosis of paratyphoid fever is the lack of a proper gold standard. Given the absence of a licensed vaccine ag...

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Autores principales: Alhaj-Qasem, Dina M., Al-Hatamleh, Mohammad A. I., Irekeola, Ahmad Adebayo, Khalid, Muhammad Fazli, Mohamud, Rohimah, Ismail, Aziah, Mustafa, Fatin Hamimi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400347/
https://www.ncbi.nlm.nih.gov/pubmed/32605310
http://dx.doi.org/10.3390/diagnostics10070438
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author Alhaj-Qasem, Dina M.
Al-Hatamleh, Mohammad A. I.
Irekeola, Ahmad Adebayo
Khalid, Muhammad Fazli
Mohamud, Rohimah
Ismail, Aziah
Mustafa, Fatin Hamimi
author_facet Alhaj-Qasem, Dina M.
Al-Hatamleh, Mohammad A. I.
Irekeola, Ahmad Adebayo
Khalid, Muhammad Fazli
Mohamud, Rohimah
Ismail, Aziah
Mustafa, Fatin Hamimi
author_sort Alhaj-Qasem, Dina M.
collection PubMed
description Paratyphoid fever is caused by the bacterium Salmonella enterica serovar Paratyphi (A, B and C), and contributes significantly to global disease burden. One of the major challenges in the diagnosis of paratyphoid fever is the lack of a proper gold standard. Given the absence of a licensed vaccine against S. Paratyphi, this diagnostic gap leads to inappropriate antibiotics use, thus, enhancing antimicrobial resistance. In addition, the symptoms of paratyphoid overlap with other infections, including the closely related typhoid fever. Since the development and utilization of a standard, sensitive, and accurate diagnostic method is essential in controlling any disease, this review discusses a new promising approach to aid the diagnosis of paratyphoid fever. This advocated approach is based on the use of surface plasmon resonance (SPR) biosensor and DNA probes to detect specific nucleic acid sequences of S. Paratyphi. We believe that this SPR-based genoassay can be a potent alternative to the current conventional diagnostic methods, and could become a rapid diagnostic tool for paratyphoid fever.
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spelling pubmed-74003472020-08-23 Laboratory Diagnosis of Paratyphoid Fever: Opportunity of Surface Plasmon Resonance Alhaj-Qasem, Dina M. Al-Hatamleh, Mohammad A. I. Irekeola, Ahmad Adebayo Khalid, Muhammad Fazli Mohamud, Rohimah Ismail, Aziah Mustafa, Fatin Hamimi Diagnostics (Basel) Review Paratyphoid fever is caused by the bacterium Salmonella enterica serovar Paratyphi (A, B and C), and contributes significantly to global disease burden. One of the major challenges in the diagnosis of paratyphoid fever is the lack of a proper gold standard. Given the absence of a licensed vaccine against S. Paratyphi, this diagnostic gap leads to inappropriate antibiotics use, thus, enhancing antimicrobial resistance. In addition, the symptoms of paratyphoid overlap with other infections, including the closely related typhoid fever. Since the development and utilization of a standard, sensitive, and accurate diagnostic method is essential in controlling any disease, this review discusses a new promising approach to aid the diagnosis of paratyphoid fever. This advocated approach is based on the use of surface plasmon resonance (SPR) biosensor and DNA probes to detect specific nucleic acid sequences of S. Paratyphi. We believe that this SPR-based genoassay can be a potent alternative to the current conventional diagnostic methods, and could become a rapid diagnostic tool for paratyphoid fever. MDPI 2020-06-28 /pmc/articles/PMC7400347/ /pubmed/32605310 http://dx.doi.org/10.3390/diagnostics10070438 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alhaj-Qasem, Dina M.
Al-Hatamleh, Mohammad A. I.
Irekeola, Ahmad Adebayo
Khalid, Muhammad Fazli
Mohamud, Rohimah
Ismail, Aziah
Mustafa, Fatin Hamimi
Laboratory Diagnosis of Paratyphoid Fever: Opportunity of Surface Plasmon Resonance
title Laboratory Diagnosis of Paratyphoid Fever: Opportunity of Surface Plasmon Resonance
title_full Laboratory Diagnosis of Paratyphoid Fever: Opportunity of Surface Plasmon Resonance
title_fullStr Laboratory Diagnosis of Paratyphoid Fever: Opportunity of Surface Plasmon Resonance
title_full_unstemmed Laboratory Diagnosis of Paratyphoid Fever: Opportunity of Surface Plasmon Resonance
title_short Laboratory Diagnosis of Paratyphoid Fever: Opportunity of Surface Plasmon Resonance
title_sort laboratory diagnosis of paratyphoid fever: opportunity of surface plasmon resonance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400347/
https://www.ncbi.nlm.nih.gov/pubmed/32605310
http://dx.doi.org/10.3390/diagnostics10070438
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