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Inhibition of UVB-Induced Inflammation by Laminaria japonica Extract via Regulation of nc886-PKR Pathway

Continuous exposure to ultraviolet B (UVB) can cause photodamage of the skin. This photodamage can be inhibited by the overexpression of the non-coding RNA, nc886, via the protein kinase RNA-activated (PKR) pathway. The study aims to identify how UVB inhibits nc886 expression, and it also seeks to d...

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Autores principales: Lee, Kwang-Soo, Cho, Eunae, Weon, Jin Bae, Park, Deokhoon, Fréchet, Mathilde, Chajra, Hanane, Jung, Eunsun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400497/
https://www.ncbi.nlm.nih.gov/pubmed/32630038
http://dx.doi.org/10.3390/nu12071958
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author Lee, Kwang-Soo
Cho, Eunae
Weon, Jin Bae
Park, Deokhoon
Fréchet, Mathilde
Chajra, Hanane
Jung, Eunsun
author_facet Lee, Kwang-Soo
Cho, Eunae
Weon, Jin Bae
Park, Deokhoon
Fréchet, Mathilde
Chajra, Hanane
Jung, Eunsun
author_sort Lee, Kwang-Soo
collection PubMed
description Continuous exposure to ultraviolet B (UVB) can cause photodamage of the skin. This photodamage can be inhibited by the overexpression of the non-coding RNA, nc886, via the protein kinase RNA-activated (PKR) pathway. The study aims to identify how UVB inhibits nc886 expression, and it also seeks to determine whether substances that can control nc886 expression can influence UV-induced inflammation, and the mechanisms involved. The results suggest that UVB irradiation accelerates the methylation of the nc886 gene, therefore, reducing its expression. This induces the activation of the PKR, which accelerates the expression of metalloproteinase-9 (MMP-9) and cyclooxygenase (COX-2), and the production of MMP-9, prostaglandin-endoperoxide synthase (PGE(2)), and certain pro-inflammatory cytokines, specifically interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α). Conversely, in a model of nc886 overexpression, the expression and production of those inflammatory factors are inhibited. In addition, Laminaria japonica extract (LJE) protect the levels of nc886 against UVB irradiation then subsequently inhibit the production of UV-induced inflammatory factors through the PKR pathway.
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spelling pubmed-74004972020-08-07 Inhibition of UVB-Induced Inflammation by Laminaria japonica Extract via Regulation of nc886-PKR Pathway Lee, Kwang-Soo Cho, Eunae Weon, Jin Bae Park, Deokhoon Fréchet, Mathilde Chajra, Hanane Jung, Eunsun Nutrients Article Continuous exposure to ultraviolet B (UVB) can cause photodamage of the skin. This photodamage can be inhibited by the overexpression of the non-coding RNA, nc886, via the protein kinase RNA-activated (PKR) pathway. The study aims to identify how UVB inhibits nc886 expression, and it also seeks to determine whether substances that can control nc886 expression can influence UV-induced inflammation, and the mechanisms involved. The results suggest that UVB irradiation accelerates the methylation of the nc886 gene, therefore, reducing its expression. This induces the activation of the PKR, which accelerates the expression of metalloproteinase-9 (MMP-9) and cyclooxygenase (COX-2), and the production of MMP-9, prostaglandin-endoperoxide synthase (PGE(2)), and certain pro-inflammatory cytokines, specifically interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α). Conversely, in a model of nc886 overexpression, the expression and production of those inflammatory factors are inhibited. In addition, Laminaria japonica extract (LJE) protect the levels of nc886 against UVB irradiation then subsequently inhibit the production of UV-induced inflammatory factors through the PKR pathway. MDPI 2020-06-30 /pmc/articles/PMC7400497/ /pubmed/32630038 http://dx.doi.org/10.3390/nu12071958 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Kwang-Soo
Cho, Eunae
Weon, Jin Bae
Park, Deokhoon
Fréchet, Mathilde
Chajra, Hanane
Jung, Eunsun
Inhibition of UVB-Induced Inflammation by Laminaria japonica Extract via Regulation of nc886-PKR Pathway
title Inhibition of UVB-Induced Inflammation by Laminaria japonica Extract via Regulation of nc886-PKR Pathway
title_full Inhibition of UVB-Induced Inflammation by Laminaria japonica Extract via Regulation of nc886-PKR Pathway
title_fullStr Inhibition of UVB-Induced Inflammation by Laminaria japonica Extract via Regulation of nc886-PKR Pathway
title_full_unstemmed Inhibition of UVB-Induced Inflammation by Laminaria japonica Extract via Regulation of nc886-PKR Pathway
title_short Inhibition of UVB-Induced Inflammation by Laminaria japonica Extract via Regulation of nc886-PKR Pathway
title_sort inhibition of uvb-induced inflammation by laminaria japonica extract via regulation of nc886-pkr pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400497/
https://www.ncbi.nlm.nih.gov/pubmed/32630038
http://dx.doi.org/10.3390/nu12071958
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