Bioinformatic Analyses of miRNA–mRNA Signature during hiPSC Differentiation towards Insulin-Producing Cells upon HNF4α Mutation

Mutations in the hepatocyte nuclear factor 4α (HNF4α) gene affect prenatal and postnatal pancreas development, being characterized by insulin-producing β-cell dysfunction. Little is known about the cellular and molecular mechanisms leading to β-cell failure as result of HNF4α mutation. In this study...

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Detalles Bibliográficos
Autores principales: Ghila, Luiza, Bjørlykke, Yngvild, Legøy, Thomas Aga, Vethe, Heidrun, Furuyama, Kenichiro, Chera, Simona, Ræder, Helge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400504/
https://www.ncbi.nlm.nih.gov/pubmed/32605028
http://dx.doi.org/10.3390/biomedicines8070179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400504/
https://www.ncbi.nlm.nih.gov/pubmed/32605028
http://dx.doi.org/10.3390/biomedicines8070179

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