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MethylResolver—a method for deconvoluting bulk DNA methylation profiles into known and unknown cell contents

Bulk tissue DNA methylation profiling has been used to examine epigenetic mechanisms and biomarkers of complex diseases such as cancer. However, heterogeneity of cellular content in tissues complicates result interpretation and utility. In silico deconvolution of cellular fractions from bulk tissue...

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Detalles Bibliográficos
Autores principales:	Arneson, Douglas, Yang, Xia, Wang, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400544/ https://www.ncbi.nlm.nih.gov/pubmed/32747663 http://dx.doi.org/10.1038/s42003-020-01146-2

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