Cargando…

Profiles of Polyphenol Intake and Type 2 Diabetes Risk in 60,586 Women Followed for 20 Years: Results from the E3N Cohort Study

Most studies on dietary polyphenol intake and type 2 diabetes (T2D) risk have focused on total or specific subclasses of polyphenols. Since polyphenols are often consumed simultaneously, the joint effect of an intake of multiple subclasses should be explored. We aimed to identify profiles of the die...

Descripción completa

Detalles Bibliográficos
Autores principales: Laouali, Nasser, Berrandou, Takiy, A. Rothwell, Joseph, Shah, Sanam, El Fatouhi, Douae, Romana Mancini, Francesca, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400616/
https://www.ncbi.nlm.nih.gov/pubmed/32610657
http://dx.doi.org/10.3390/nu12071934
_version_ 1783566404610424832
author Laouali, Nasser
Berrandou, Takiy
A. Rothwell, Joseph
Shah, Sanam
El Fatouhi, Douae
Romana Mancini, Francesca
Boutron-Ruault, Marie-Christine
Fagherazzi, Guy
author_facet Laouali, Nasser
Berrandou, Takiy
A. Rothwell, Joseph
Shah, Sanam
El Fatouhi, Douae
Romana Mancini, Francesca
Boutron-Ruault, Marie-Christine
Fagherazzi, Guy
author_sort Laouali, Nasser
collection PubMed
description Most studies on dietary polyphenol intake and type 2 diabetes (T2D) risk have focused on total or specific subclasses of polyphenols. Since polyphenols are often consumed simultaneously, the joint effect of an intake of multiple subclasses should be explored. We aimed to identify profiles of the dietary polyphenol subclasses intake associated with T2D. A total of 60,586 women from the Etude Epidémiologique auprès de femmes de l’Education Nationale (E3N) cohort study were followed for 20 years between 1993 and 2014. T2D cases were identified and validated. The individual energy-adjusted daily intakes of 15 subclasses of polyphenols were estimated at baseline using a food frequency questionnaire and the PhenolExplorer database. We used Bayesian profile regression to perform the clustering of the covariates by identifying exposure profiles of polyphenol intakes and, simultaneously, link these to T2D risk by using multivariable Cox regression models. We validated 2740 incident T2D cases during follow-up, and identified 15 distinct clusters with different intake profiles and T2D risk. When compared to the largest cluster (n = 6298 women), higher risks of T2D were observed in three of those clusters, which were composed of women with low or medium intakes of anthocyanins, dihydroflavonols, catechins, flavonols, hydroxybenzoic acids, lignans, and stilbenes. One cluster (n = 4243), characterized by higher intakes of these polyphenol subclasses, exhibited lower T2D risk when compared to the reference cluster. These results highlight the importance of a varied diet of polyphenol-rich foods such as nuts, fruits, and vegetables to prevent T2D risk.
format Online
Article
Text
id pubmed-7400616
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74006162020-08-07 Profiles of Polyphenol Intake and Type 2 Diabetes Risk in 60,586 Women Followed for 20 Years: Results from the E3N Cohort Study Laouali, Nasser Berrandou, Takiy A. Rothwell, Joseph Shah, Sanam El Fatouhi, Douae Romana Mancini, Francesca Boutron-Ruault, Marie-Christine Fagherazzi, Guy Nutrients Brief Report Most studies on dietary polyphenol intake and type 2 diabetes (T2D) risk have focused on total or specific subclasses of polyphenols. Since polyphenols are often consumed simultaneously, the joint effect of an intake of multiple subclasses should be explored. We aimed to identify profiles of the dietary polyphenol subclasses intake associated with T2D. A total of 60,586 women from the Etude Epidémiologique auprès de femmes de l’Education Nationale (E3N) cohort study were followed for 20 years between 1993 and 2014. T2D cases were identified and validated. The individual energy-adjusted daily intakes of 15 subclasses of polyphenols were estimated at baseline using a food frequency questionnaire and the PhenolExplorer database. We used Bayesian profile regression to perform the clustering of the covariates by identifying exposure profiles of polyphenol intakes and, simultaneously, link these to T2D risk by using multivariable Cox regression models. We validated 2740 incident T2D cases during follow-up, and identified 15 distinct clusters with different intake profiles and T2D risk. When compared to the largest cluster (n = 6298 women), higher risks of T2D were observed in three of those clusters, which were composed of women with low or medium intakes of anthocyanins, dihydroflavonols, catechins, flavonols, hydroxybenzoic acids, lignans, and stilbenes. One cluster (n = 4243), characterized by higher intakes of these polyphenol subclasses, exhibited lower T2D risk when compared to the reference cluster. These results highlight the importance of a varied diet of polyphenol-rich foods such as nuts, fruits, and vegetables to prevent T2D risk. MDPI 2020-06-29 /pmc/articles/PMC7400616/ /pubmed/32610657 http://dx.doi.org/10.3390/nu12071934 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Laouali, Nasser
Berrandou, Takiy
A. Rothwell, Joseph
Shah, Sanam
El Fatouhi, Douae
Romana Mancini, Francesca
Boutron-Ruault, Marie-Christine
Fagherazzi, Guy
Profiles of Polyphenol Intake and Type 2 Diabetes Risk in 60,586 Women Followed for 20 Years: Results from the E3N Cohort Study
title Profiles of Polyphenol Intake and Type 2 Diabetes Risk in 60,586 Women Followed for 20 Years: Results from the E3N Cohort Study
title_full Profiles of Polyphenol Intake and Type 2 Diabetes Risk in 60,586 Women Followed for 20 Years: Results from the E3N Cohort Study
title_fullStr Profiles of Polyphenol Intake and Type 2 Diabetes Risk in 60,586 Women Followed for 20 Years: Results from the E3N Cohort Study
title_full_unstemmed Profiles of Polyphenol Intake and Type 2 Diabetes Risk in 60,586 Women Followed for 20 Years: Results from the E3N Cohort Study
title_short Profiles of Polyphenol Intake and Type 2 Diabetes Risk in 60,586 Women Followed for 20 Years: Results from the E3N Cohort Study
title_sort profiles of polyphenol intake and type 2 diabetes risk in 60,586 women followed for 20 years: results from the e3n cohort study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400616/
https://www.ncbi.nlm.nih.gov/pubmed/32610657
http://dx.doi.org/10.3390/nu12071934
work_keys_str_mv AT laoualinasser profilesofpolyphenolintakeandtype2diabetesriskin60586womenfollowedfor20yearsresultsfromthee3ncohortstudy
AT berrandoutakiy profilesofpolyphenolintakeandtype2diabetesriskin60586womenfollowedfor20yearsresultsfromthee3ncohortstudy
AT arothwelljoseph profilesofpolyphenolintakeandtype2diabetesriskin60586womenfollowedfor20yearsresultsfromthee3ncohortstudy
AT shahsanam profilesofpolyphenolintakeandtype2diabetesriskin60586womenfollowedfor20yearsresultsfromthee3ncohortstudy
AT elfatouhidouae profilesofpolyphenolintakeandtype2diabetesriskin60586womenfollowedfor20yearsresultsfromthee3ncohortstudy
AT romanamancinifrancesca profilesofpolyphenolintakeandtype2diabetesriskin60586womenfollowedfor20yearsresultsfromthee3ncohortstudy
AT boutronruaultmariechristine profilesofpolyphenolintakeandtype2diabetesriskin60586womenfollowedfor20yearsresultsfromthee3ncohortstudy
AT fagherazziguy profilesofpolyphenolintakeandtype2diabetesriskin60586womenfollowedfor20yearsresultsfromthee3ncohortstudy