Cargando…
Structural and Bioactivity Characterization of Filipin Derivatives from Engineered Streptomyces filipinensis Strains Reveals Clues for Reduced Haemolytic Action
The rise in the number of immunocompromised patients has led to an increased incidence of fungal infections, with high rates of morbidity and mortality. Furthermore, misuse of antifungals has boosted the number of resistant strains to these agents; thus, there is urgent need for new drugs against th...
Autores principales: | Barreales, Eva G., Rumbero, Ángel, Payero, Tamara D., de Pedro, Antonio, Jambrina, Ester, Aparicio, Jesús F. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400637/ https://www.ncbi.nlm.nih.gov/pubmed/32708546 http://dx.doi.org/10.3390/antibiotics9070413 |
Ejemplares similares
-
Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives
por: Payero, Tamara D, et al.
Publicado: (2015) -
The Streptomyces filipinensis Gamma-Butyrolactone System Reveals Novel Clues for Understanding the Control of Secondary Metabolism
por: Barreales, Eva G., et al.
Publicado: (2020) -
Phosphate effect on filipin production and morphological differentiation in Streptomyces filipinensis and the role of the PhoP transcription factor
por: Barreales, Eva G., et al.
Publicado: (2018) -
Promoter Engineering Reveals the Importance of Heptameric Direct Repeats for DNA Binding by Streptomyces Antibiotic Regulatory Protein–Large ATP-Binding Regulator of the LuxR Family (SARP-LAL) Regulators in Streptomyces natalensis
por: Barreales, Eva G., et al.
Publicado: (2018) -
Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation
por: Aparicio, Jesús F., et al.
Publicado: (2015)