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Impact of Case Definitions on Efficacy Estimation in Clinical Trials—A Proof-of-Principle Based on Historical Examples

Efficacy estimations in clinical trials are based on case definitions. Commonly, they are a more or less complex set of conditions that have to be fulfilled in order to define a clinical case. In the simplest variant, such a case is identical with a single positive diagnostic test result. Frequently...

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Detalles Bibliográficos
Autores principales: Hahn, Andreas, Frickmann, Hagen, Zautner, Andreas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400704/
https://www.ncbi.nlm.nih.gov/pubmed/32635553
http://dx.doi.org/10.3390/antibiotics9070379

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