Functional definition of a transcription factor hierarchy regulating T cell lineage commitment

T cell factor 1 (Tcf1) is the first T cell–specific protein induced by Notch signaling in the thymus, leading to the activation of two major target genes, Gata3 and Bcl11b. Tcf1 deficiency results in partial arrests in T cell development, high apoptosis, and increased development of B and myeloid ce...

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Detalles Bibliográficos
Autores principales: Garcia-Perez, Laura, Famili, Farbod, Cordes, Martijn, Brugman, Martijn, van Eggermond, Marja, Wu, Haoyu, Chouaref, Jihed, Granado, David San León, Tiemessen, Machteld M., Pike-Overzet, Karin, Daxinger, Lucia, Staal, Frank J. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400773/
https://www.ncbi.nlm.nih.gov/pubmed/32789164
http://dx.doi.org/10.1126/sciadv.aaw7313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400773/
https://www.ncbi.nlm.nih.gov/pubmed/32789164
http://dx.doi.org/10.1126/sciadv.aaw7313

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