Cargando…

Lower Energy Intake among Advanced vs. Early Parkinson’s Disease Patients and Healthy Controls in a Clinical Lunch Setting: A Cross-Sectional Study

Unintentional weight loss has been observed among Parkinson’s disease (PD) patients. Changes in energy intake (EI) and eating behavior, potentially caused by fine motor dysfunction and eating-related symptoms, might contribute to this. The primary aim of this study was to investigate differences in...

Descripción completa

Detalles Bibliográficos
Autores principales: Fagerberg, Petter, Klingelhoefer, Lisa, Bottai, Matteo, Langlet, Billy, Kyritsis, Konstantinos, Rotter, Eva, Reichmann, Heinz, Falkenburger, Björn, Delopoulos, Anastasios, Ioakimidis, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400863/
https://www.ncbi.nlm.nih.gov/pubmed/32708668
http://dx.doi.org/10.3390/nu12072109
_version_ 1783566455574364160
author Fagerberg, Petter
Klingelhoefer, Lisa
Bottai, Matteo
Langlet, Billy
Kyritsis, Konstantinos
Rotter, Eva
Reichmann, Heinz
Falkenburger, Björn
Delopoulos, Anastasios
Ioakimidis, Ioannis
author_facet Fagerberg, Petter
Klingelhoefer, Lisa
Bottai, Matteo
Langlet, Billy
Kyritsis, Konstantinos
Rotter, Eva
Reichmann, Heinz
Falkenburger, Björn
Delopoulos, Anastasios
Ioakimidis, Ioannis
author_sort Fagerberg, Petter
collection PubMed
description Unintentional weight loss has been observed among Parkinson’s disease (PD) patients. Changes in energy intake (EI) and eating behavior, potentially caused by fine motor dysfunction and eating-related symptoms, might contribute to this. The primary aim of this study was to investigate differences in objectively measured EI between groups of healthy controls (HC), early (ESPD) and advanced stage PD patients (ASPD) during a standardized lunch in a clinical setting. The secondary aim was to identify clinical features and eating behavior abnormalities that explain EI differences. All participants (n = 23 HC, n = 20 ESPD, and n = 21 ASPD) went through clinical evaluations and were eating a standardized meal (200 g sausages, 400 g potato salad, 200 g apple purée and 500 mL water) in front of two video cameras. Participants ate freely, and the food was weighed pre- and post-meal to calculate EI (kcal). Multiple linear regression was used to explain group differences in EI. ASPD had a significantly lower EI vs. HC (−162 kcal, p < 0.05) and vs. ESPD (−203 kcal, p < 0.01) when controlling for sex. The number of spoonfuls, eating problems, dysphagia and upper extremity tremor could explain most (86%) of the lower EI vs. HC, while the first three could explain ~50% vs. ESPD. Food component intake analysis revealed significantly lower potato salad and sausage intakes among ASPD vs. both HC and ESPD, while water intake was lower vs. HC. EI is an important clinical target for PD patients with an increased risk of weight loss. Our results suggest that interventions targeting upper extremity tremor, spoonfuls, dysphagia and eating problems might be clinically useful in the prevention of unintentional weight loss in PD. Since EI was lower in ASPD, EI might be a useful marker of disease progression in PD.
format Online
Article
Text
id pubmed-7400863
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74008632020-08-07 Lower Energy Intake among Advanced vs. Early Parkinson’s Disease Patients and Healthy Controls in a Clinical Lunch Setting: A Cross-Sectional Study Fagerberg, Petter Klingelhoefer, Lisa Bottai, Matteo Langlet, Billy Kyritsis, Konstantinos Rotter, Eva Reichmann, Heinz Falkenburger, Björn Delopoulos, Anastasios Ioakimidis, Ioannis Nutrients Article Unintentional weight loss has been observed among Parkinson’s disease (PD) patients. Changes in energy intake (EI) and eating behavior, potentially caused by fine motor dysfunction and eating-related symptoms, might contribute to this. The primary aim of this study was to investigate differences in objectively measured EI between groups of healthy controls (HC), early (ESPD) and advanced stage PD patients (ASPD) during a standardized lunch in a clinical setting. The secondary aim was to identify clinical features and eating behavior abnormalities that explain EI differences. All participants (n = 23 HC, n = 20 ESPD, and n = 21 ASPD) went through clinical evaluations and were eating a standardized meal (200 g sausages, 400 g potato salad, 200 g apple purée and 500 mL water) in front of two video cameras. Participants ate freely, and the food was weighed pre- and post-meal to calculate EI (kcal). Multiple linear regression was used to explain group differences in EI. ASPD had a significantly lower EI vs. HC (−162 kcal, p < 0.05) and vs. ESPD (−203 kcal, p < 0.01) when controlling for sex. The number of spoonfuls, eating problems, dysphagia and upper extremity tremor could explain most (86%) of the lower EI vs. HC, while the first three could explain ~50% vs. ESPD. Food component intake analysis revealed significantly lower potato salad and sausage intakes among ASPD vs. both HC and ESPD, while water intake was lower vs. HC. EI is an important clinical target for PD patients with an increased risk of weight loss. Our results suggest that interventions targeting upper extremity tremor, spoonfuls, dysphagia and eating problems might be clinically useful in the prevention of unintentional weight loss in PD. Since EI was lower in ASPD, EI might be a useful marker of disease progression in PD. MDPI 2020-07-16 /pmc/articles/PMC7400863/ /pubmed/32708668 http://dx.doi.org/10.3390/nu12072109 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fagerberg, Petter
Klingelhoefer, Lisa
Bottai, Matteo
Langlet, Billy
Kyritsis, Konstantinos
Rotter, Eva
Reichmann, Heinz
Falkenburger, Björn
Delopoulos, Anastasios
Ioakimidis, Ioannis
Lower Energy Intake among Advanced vs. Early Parkinson’s Disease Patients and Healthy Controls in a Clinical Lunch Setting: A Cross-Sectional Study
title Lower Energy Intake among Advanced vs. Early Parkinson’s Disease Patients and Healthy Controls in a Clinical Lunch Setting: A Cross-Sectional Study
title_full Lower Energy Intake among Advanced vs. Early Parkinson’s Disease Patients and Healthy Controls in a Clinical Lunch Setting: A Cross-Sectional Study
title_fullStr Lower Energy Intake among Advanced vs. Early Parkinson’s Disease Patients and Healthy Controls in a Clinical Lunch Setting: A Cross-Sectional Study
title_full_unstemmed Lower Energy Intake among Advanced vs. Early Parkinson’s Disease Patients and Healthy Controls in a Clinical Lunch Setting: A Cross-Sectional Study
title_short Lower Energy Intake among Advanced vs. Early Parkinson’s Disease Patients and Healthy Controls in a Clinical Lunch Setting: A Cross-Sectional Study
title_sort lower energy intake among advanced vs. early parkinson’s disease patients and healthy controls in a clinical lunch setting: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400863/
https://www.ncbi.nlm.nih.gov/pubmed/32708668
http://dx.doi.org/10.3390/nu12072109
work_keys_str_mv AT fagerbergpetter lowerenergyintakeamongadvancedvsearlyparkinsonsdiseasepatientsandhealthycontrolsinaclinicallunchsettingacrosssectionalstudy
AT klingelhoeferlisa lowerenergyintakeamongadvancedvsearlyparkinsonsdiseasepatientsandhealthycontrolsinaclinicallunchsettingacrosssectionalstudy
AT bottaimatteo lowerenergyintakeamongadvancedvsearlyparkinsonsdiseasepatientsandhealthycontrolsinaclinicallunchsettingacrosssectionalstudy
AT langletbilly lowerenergyintakeamongadvancedvsearlyparkinsonsdiseasepatientsandhealthycontrolsinaclinicallunchsettingacrosssectionalstudy
AT kyritsiskonstantinos lowerenergyintakeamongadvancedvsearlyparkinsonsdiseasepatientsandhealthycontrolsinaclinicallunchsettingacrosssectionalstudy
AT rottereva lowerenergyintakeamongadvancedvsearlyparkinsonsdiseasepatientsandhealthycontrolsinaclinicallunchsettingacrosssectionalstudy
AT reichmannheinz lowerenergyintakeamongadvancedvsearlyparkinsonsdiseasepatientsandhealthycontrolsinaclinicallunchsettingacrosssectionalstudy
AT falkenburgerbjorn lowerenergyintakeamongadvancedvsearlyparkinsonsdiseasepatientsandhealthycontrolsinaclinicallunchsettingacrosssectionalstudy
AT delopoulosanastasios lowerenergyintakeamongadvancedvsearlyparkinsonsdiseasepatientsandhealthycontrolsinaclinicallunchsettingacrosssectionalstudy
AT ioakimidisioannis lowerenergyintakeamongadvancedvsearlyparkinsonsdiseasepatientsandhealthycontrolsinaclinicallunchsettingacrosssectionalstudy