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Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer
Up to 60% of colorectal cancer (CRC) patients develop malnutrition, affecting treatment effectiveness, increasing toxicity, postoperative complications, hospital stay, and worsening health-related quality of life (HRQOL). This cross-sectional study analyzed data from 48 women and 65 men with CRC. We...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400949/ https://www.ncbi.nlm.nih.gov/pubmed/32708665 http://dx.doi.org/10.3390/nu12072110 |
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author | Balderas-Peña, Luz-Ma-Adriana González-Barba, Faviola Martínez-Herrera, Brenda-Eugenia Palomares-Chacón, Ulises-Rodrigo Durán-Anguiano, Oscar Salazar-Páramo, Mario Gómez-Sánchez, Eduardo Dávalos-Cobián, Carlos Nava-Zavala, Arnulfo-Hernán Hernández-Chávez, Guillermo-Allan Sat-Muñoz, Daniel |
author_facet | Balderas-Peña, Luz-Ma-Adriana González-Barba, Faviola Martínez-Herrera, Brenda-Eugenia Palomares-Chacón, Ulises-Rodrigo Durán-Anguiano, Oscar Salazar-Páramo, Mario Gómez-Sánchez, Eduardo Dávalos-Cobián, Carlos Nava-Zavala, Arnulfo-Hernán Hernández-Chávez, Guillermo-Allan Sat-Muñoz, Daniel |
author_sort | Balderas-Peña, Luz-Ma-Adriana |
collection | PubMed |
description | Up to 60% of colorectal cancer (CRC) patients develop malnutrition, affecting treatment effectiveness, increasing toxicity, postoperative complications, hospital stay, and worsening health-related quality of life (HRQOL). This cross-sectional study analyzed data from 48 women and 65 men with CRC. We correlated scores of the scales from the questionnaires EORTC (European Organisation for Research and Treatment of Cancer) Quality of Life Questionnaire Core 30 (QLQ)-C30 and Colorectal Cancer module Colorectal 29 (QLQ-CR29) with patients’ body composition and clinical and biochemical indicators of nutritional status. Results: Scores on quality of life were negatively associated with the lymphocyte count (rP = −0.386) and the fat trunk percentage (rP = −0.349) in the women’s group. Scores on the physical and role functioning were inversely associated with the adiposity percentage (rP = −0.486 and rP = −0.411, respectively). In men, total skeletal muscle mass (SMM) was positively associated with emotional functioning (rP = 0.450); the trunk SMM was negatively related to fatigue (rP = −0.586), nausea and vomiting (rP = −0.469), pain (rP = −0.506), and financial difficulties (rP = −0.475); additionally, serum albumin was positively related to physical, emotional, and social functioning scales (rPs = 0.395, 0.453, and 0.363, respectively) and negatively to fatigue (rP = −0.362), nausea and vomiting (rP = −0.387), and appetite loss (rP = −0.347). Among the men, the reduced SMM and biochemical, nutritional parameters were related to low scores on the EORTC QLQ-C30 and QLQ-CR29 functioning scales. In conclusion, in patients with CRC, malnourishment could have a profound effect on the patients’ functionality and QoL (quality of life). |
format | Online Article Text |
id | pubmed-7400949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74009492020-08-07 Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer Balderas-Peña, Luz-Ma-Adriana González-Barba, Faviola Martínez-Herrera, Brenda-Eugenia Palomares-Chacón, Ulises-Rodrigo Durán-Anguiano, Oscar Salazar-Páramo, Mario Gómez-Sánchez, Eduardo Dávalos-Cobián, Carlos Nava-Zavala, Arnulfo-Hernán Hernández-Chávez, Guillermo-Allan Sat-Muñoz, Daniel Nutrients Article Up to 60% of colorectal cancer (CRC) patients develop malnutrition, affecting treatment effectiveness, increasing toxicity, postoperative complications, hospital stay, and worsening health-related quality of life (HRQOL). This cross-sectional study analyzed data from 48 women and 65 men with CRC. We correlated scores of the scales from the questionnaires EORTC (European Organisation for Research and Treatment of Cancer) Quality of Life Questionnaire Core 30 (QLQ)-C30 and Colorectal Cancer module Colorectal 29 (QLQ-CR29) with patients’ body composition and clinical and biochemical indicators of nutritional status. Results: Scores on quality of life were negatively associated with the lymphocyte count (rP = −0.386) and the fat trunk percentage (rP = −0.349) in the women’s group. Scores on the physical and role functioning were inversely associated with the adiposity percentage (rP = −0.486 and rP = −0.411, respectively). In men, total skeletal muscle mass (SMM) was positively associated with emotional functioning (rP = 0.450); the trunk SMM was negatively related to fatigue (rP = −0.586), nausea and vomiting (rP = −0.469), pain (rP = −0.506), and financial difficulties (rP = −0.475); additionally, serum albumin was positively related to physical, emotional, and social functioning scales (rPs = 0.395, 0.453, and 0.363, respectively) and negatively to fatigue (rP = −0.362), nausea and vomiting (rP = −0.387), and appetite loss (rP = −0.347). Among the men, the reduced SMM and biochemical, nutritional parameters were related to low scores on the EORTC QLQ-C30 and QLQ-CR29 functioning scales. In conclusion, in patients with CRC, malnourishment could have a profound effect on the patients’ functionality and QoL (quality of life). MDPI 2020-07-16 /pmc/articles/PMC7400949/ /pubmed/32708665 http://dx.doi.org/10.3390/nu12072110 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Balderas-Peña, Luz-Ma-Adriana González-Barba, Faviola Martínez-Herrera, Brenda-Eugenia Palomares-Chacón, Ulises-Rodrigo Durán-Anguiano, Oscar Salazar-Páramo, Mario Gómez-Sánchez, Eduardo Dávalos-Cobián, Carlos Nava-Zavala, Arnulfo-Hernán Hernández-Chávez, Guillermo-Allan Sat-Muñoz, Daniel Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer |
title | Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer |
title_full | Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer |
title_fullStr | Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer |
title_full_unstemmed | Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer |
title_short | Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer |
title_sort | body composition and biochemical parameters of nutritional status: correlation with health-related quality of life in patients with colorectal cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400949/ https://www.ncbi.nlm.nih.gov/pubmed/32708665 http://dx.doi.org/10.3390/nu12072110 |
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