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Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer

Up to 60% of colorectal cancer (CRC) patients develop malnutrition, affecting treatment effectiveness, increasing toxicity, postoperative complications, hospital stay, and worsening health-related quality of life (HRQOL). This cross-sectional study analyzed data from 48 women and 65 men with CRC. We...

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Autores principales: Balderas-Peña, Luz-Ma-Adriana, González-Barba, Faviola, Martínez-Herrera, Brenda-Eugenia, Palomares-Chacón, Ulises-Rodrigo, Durán-Anguiano, Oscar, Salazar-Páramo, Mario, Gómez-Sánchez, Eduardo, Dávalos-Cobián, Carlos, Nava-Zavala, Arnulfo-Hernán, Hernández-Chávez, Guillermo-Allan, Sat-Muñoz, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400949/
https://www.ncbi.nlm.nih.gov/pubmed/32708665
http://dx.doi.org/10.3390/nu12072110
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author Balderas-Peña, Luz-Ma-Adriana
González-Barba, Faviola
Martínez-Herrera, Brenda-Eugenia
Palomares-Chacón, Ulises-Rodrigo
Durán-Anguiano, Oscar
Salazar-Páramo, Mario
Gómez-Sánchez, Eduardo
Dávalos-Cobián, Carlos
Nava-Zavala, Arnulfo-Hernán
Hernández-Chávez, Guillermo-Allan
Sat-Muñoz, Daniel
author_facet Balderas-Peña, Luz-Ma-Adriana
González-Barba, Faviola
Martínez-Herrera, Brenda-Eugenia
Palomares-Chacón, Ulises-Rodrigo
Durán-Anguiano, Oscar
Salazar-Páramo, Mario
Gómez-Sánchez, Eduardo
Dávalos-Cobián, Carlos
Nava-Zavala, Arnulfo-Hernán
Hernández-Chávez, Guillermo-Allan
Sat-Muñoz, Daniel
author_sort Balderas-Peña, Luz-Ma-Adriana
collection PubMed
description Up to 60% of colorectal cancer (CRC) patients develop malnutrition, affecting treatment effectiveness, increasing toxicity, postoperative complications, hospital stay, and worsening health-related quality of life (HRQOL). This cross-sectional study analyzed data from 48 women and 65 men with CRC. We correlated scores of the scales from the questionnaires EORTC (European Organisation for Research and Treatment of Cancer) Quality of Life Questionnaire Core 30 (QLQ)-C30 and Colorectal Cancer module Colorectal 29 (QLQ-CR29) with patients’ body composition and clinical and biochemical indicators of nutritional status. Results: Scores on quality of life were negatively associated with the lymphocyte count (rP = −0.386) and the fat trunk percentage (rP = −0.349) in the women’s group. Scores on the physical and role functioning were inversely associated with the adiposity percentage (rP = −0.486 and rP = −0.411, respectively). In men, total skeletal muscle mass (SMM) was positively associated with emotional functioning (rP = 0.450); the trunk SMM was negatively related to fatigue (rP = −0.586), nausea and vomiting (rP = −0.469), pain (rP = −0.506), and financial difficulties (rP = −0.475); additionally, serum albumin was positively related to physical, emotional, and social functioning scales (rPs = 0.395, 0.453, and 0.363, respectively) and negatively to fatigue (rP = −0.362), nausea and vomiting (rP = −0.387), and appetite loss (rP = −0.347). Among the men, the reduced SMM and biochemical, nutritional parameters were related to low scores on the EORTC QLQ-C30 and QLQ-CR29 functioning scales. In conclusion, in patients with CRC, malnourishment could have a profound effect on the patients’ functionality and QoL (quality of life).
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spelling pubmed-74009492020-08-07 Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer Balderas-Peña, Luz-Ma-Adriana González-Barba, Faviola Martínez-Herrera, Brenda-Eugenia Palomares-Chacón, Ulises-Rodrigo Durán-Anguiano, Oscar Salazar-Páramo, Mario Gómez-Sánchez, Eduardo Dávalos-Cobián, Carlos Nava-Zavala, Arnulfo-Hernán Hernández-Chávez, Guillermo-Allan Sat-Muñoz, Daniel Nutrients Article Up to 60% of colorectal cancer (CRC) patients develop malnutrition, affecting treatment effectiveness, increasing toxicity, postoperative complications, hospital stay, and worsening health-related quality of life (HRQOL). This cross-sectional study analyzed data from 48 women and 65 men with CRC. We correlated scores of the scales from the questionnaires EORTC (European Organisation for Research and Treatment of Cancer) Quality of Life Questionnaire Core 30 (QLQ)-C30 and Colorectal Cancer module Colorectal 29 (QLQ-CR29) with patients’ body composition and clinical and biochemical indicators of nutritional status. Results: Scores on quality of life were negatively associated with the lymphocyte count (rP = −0.386) and the fat trunk percentage (rP = −0.349) in the women’s group. Scores on the physical and role functioning were inversely associated with the adiposity percentage (rP = −0.486 and rP = −0.411, respectively). In men, total skeletal muscle mass (SMM) was positively associated with emotional functioning (rP = 0.450); the trunk SMM was negatively related to fatigue (rP = −0.586), nausea and vomiting (rP = −0.469), pain (rP = −0.506), and financial difficulties (rP = −0.475); additionally, serum albumin was positively related to physical, emotional, and social functioning scales (rPs = 0.395, 0.453, and 0.363, respectively) and negatively to fatigue (rP = −0.362), nausea and vomiting (rP = −0.387), and appetite loss (rP = −0.347). Among the men, the reduced SMM and biochemical, nutritional parameters were related to low scores on the EORTC QLQ-C30 and QLQ-CR29 functioning scales. In conclusion, in patients with CRC, malnourishment could have a profound effect on the patients’ functionality and QoL (quality of life). MDPI 2020-07-16 /pmc/articles/PMC7400949/ /pubmed/32708665 http://dx.doi.org/10.3390/nu12072110 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Balderas-Peña, Luz-Ma-Adriana
González-Barba, Faviola
Martínez-Herrera, Brenda-Eugenia
Palomares-Chacón, Ulises-Rodrigo
Durán-Anguiano, Oscar
Salazar-Páramo, Mario
Gómez-Sánchez, Eduardo
Dávalos-Cobián, Carlos
Nava-Zavala, Arnulfo-Hernán
Hernández-Chávez, Guillermo-Allan
Sat-Muñoz, Daniel
Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer
title Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer
title_full Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer
title_fullStr Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer
title_full_unstemmed Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer
title_short Body Composition and Biochemical Parameters of Nutritional Status: Correlation with Health-Related Quality of Life in Patients with Colorectal Cancer
title_sort body composition and biochemical parameters of nutritional status: correlation with health-related quality of life in patients with colorectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400949/
https://www.ncbi.nlm.nih.gov/pubmed/32708665
http://dx.doi.org/10.3390/nu12072110
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