HIV, progestins, genital epithelial barrier function, and the burden of objectivity

Contributions from a diverse set of scientific disciplines will be needed to help individuals make fully informed decisions regarding contraceptive choices least likely to promote HIV susceptibility. This commentary recaps contrasting interpretations of results from the Evidence for Contraceptive Op...

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Detalles Bibliográficos
Autores principales: Vicetti Miguel, Rodolfo D, Quispe Calla, Nirk E, Cherpes, Thomas L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Contraceptive Special Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401028/
https://www.ncbi.nlm.nih.gov/pubmed/32561906
http://dx.doi.org/10.1093/biolre/ioaa078
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author Vicetti Miguel, Rodolfo D
Quispe Calla, Nirk E
Cherpes, Thomas L
author_facet Vicetti Miguel, Rodolfo D
Quispe Calla, Nirk E
Cherpes, Thomas L
author_sort Vicetti Miguel, Rodolfo D
collection PubMed
description Contributions from a diverse set of scientific disciplines will be needed to help individuals make fully informed decisions regarding contraceptive choices least likely to promote HIV susceptibility. This commentary recaps contrasting interpretations of results from the Evidence for Contraceptive Options and HIV Outcomes (ECHO) Trial, a study that compared HIV risk in women using the progestin-only injectable contraceptive depot medroxyprogesterone acetate (DMPA) vs. two other contraceptive choices. It also summarizes results from basic and translational research that establish biological plausibility for earlier clinical studies that identified enhanced HIV susceptibility in women using DMPA.
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spelling pubmed-74010282020-09-30 HIV, progestins, genital epithelial barrier function, and the burden of objectivity Vicetti Miguel, Rodolfo D Quispe Calla, Nirk E Cherpes, Thomas L Biol Reprod Contraceptive Special Issue Contributions from a diverse set of scientific disciplines will be needed to help individuals make fully informed decisions regarding contraceptive choices least likely to promote HIV susceptibility. This commentary recaps contrasting interpretations of results from the Evidence for Contraceptive Options and HIV Outcomes (ECHO) Trial, a study that compared HIV risk in women using the progestin-only injectable contraceptive depot medroxyprogesterone acetate (DMPA) vs. two other contraceptive choices. It also summarizes results from basic and translational research that establish biological plausibility for earlier clinical studies that identified enhanced HIV susceptibility in women using DMPA. Oxford University Press 2020-08 2020-05-15 /pmc/articles/PMC7401028/ /pubmed/32561906 http://dx.doi.org/10.1093/biolre/ioaa078 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Society for the Study of Reproduction. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Contraceptive Special Issue
Vicetti Miguel, Rodolfo D
Quispe Calla, Nirk E
Cherpes, Thomas L
HIV, progestins, genital epithelial barrier function, and the burden of objectivity
title HIV, progestins, genital epithelial barrier function, and the burden of objectivity
title_full HIV, progestins, genital epithelial barrier function, and the burden of objectivity
title_fullStr HIV, progestins, genital epithelial barrier function, and the burden of objectivity
title_full_unstemmed HIV, progestins, genital epithelial barrier function, and the burden of objectivity
title_short HIV, progestins, genital epithelial barrier function, and the burden of objectivity
title_sort hiv, progestins, genital epithelial barrier function, and the burden of objectivity
topic Contraceptive Special Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401028/
https://www.ncbi.nlm.nih.gov/pubmed/32561906
http://dx.doi.org/10.1093/biolre/ioaa078
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