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The new contraceptive revolution: developing innovative products outside of industry(†,‡)
A significant global unmet need for new contraceptive options for both women and men remains due to side effect profiles, medical concerns, and inconvenience of many currently available products. The pharmaceutical industry has largely abandoned early research and development for contraception and w...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401029/ https://www.ncbi.nlm.nih.gov/pubmed/32529250 http://dx.doi.org/10.1093/biolre/ioaa067 |
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author | Callahan, Rebecca L Mehta, Neha J Nanda, Kavita Kopf, Gregory S |
author_facet | Callahan, Rebecca L Mehta, Neha J Nanda, Kavita Kopf, Gregory S |
author_sort | Callahan, Rebecca L |
collection | PubMed |
description | A significant global unmet need for new contraceptive options for both women and men remains due to side effect profiles, medical concerns, and inconvenience of many currently available products. The pharmaceutical industry has largely abandoned early research and development for contraception and will not likely engage to bring new products to the market unless they have been significantly de-risked by showing promise in early phase clinical trials. This lack of interest by big pharma comes at a time when scientific and technological advances in biology and medicine are creating more opportunities than ever for the development of new and innovative drug products. Novel partnerships between the academic sector, small biotechnology companies, foundations, non-government organizations (NGOs), and the federal government could accelerate the development of new contraceptive products. We discuss the challenges and opportunities that we have encountered as an NGO with a mission to develop novel contraceptive products for low- and middle-income countries and how it differs from developing products for higher-income markets. We hope that our experiences and “lessons learned” will be of value to others as they proceed down the product development path, be it for female or male or for hormonal or nonhormonal contraceptives. |
format | Online Article Text |
id | pubmed-7401029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-74010292020-08-06 The new contraceptive revolution: developing innovative products outside of industry(†,‡) Callahan, Rebecca L Mehta, Neha J Nanda, Kavita Kopf, Gregory S Biol Reprod Contraceptive Special Issue A significant global unmet need for new contraceptive options for both women and men remains due to side effect profiles, medical concerns, and inconvenience of many currently available products. The pharmaceutical industry has largely abandoned early research and development for contraception and will not likely engage to bring new products to the market unless they have been significantly de-risked by showing promise in early phase clinical trials. This lack of interest by big pharma comes at a time when scientific and technological advances in biology and medicine are creating more opportunities than ever for the development of new and innovative drug products. Novel partnerships between the academic sector, small biotechnology companies, foundations, non-government organizations (NGOs), and the federal government could accelerate the development of new contraceptive products. We discuss the challenges and opportunities that we have encountered as an NGO with a mission to develop novel contraceptive products for low- and middle-income countries and how it differs from developing products for higher-income markets. We hope that our experiences and “lessons learned” will be of value to others as they proceed down the product development path, be it for female or male or for hormonal or nonhormonal contraceptives. Oxford University Press 2020-08 2020-05-09 /pmc/articles/PMC7401029/ /pubmed/32529250 http://dx.doi.org/10.1093/biolre/ioaa067 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Society for the Study of Reproduction. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Contraceptive Special Issue Callahan, Rebecca L Mehta, Neha J Nanda, Kavita Kopf, Gregory S The new contraceptive revolution: developing innovative products outside of industry(†,‡) |
title | The new contraceptive revolution: developing innovative products outside of industry(†,‡) |
title_full | The new contraceptive revolution: developing innovative products outside of industry(†,‡) |
title_fullStr | The new contraceptive revolution: developing innovative products outside of industry(†,‡) |
title_full_unstemmed | The new contraceptive revolution: developing innovative products outside of industry(†,‡) |
title_short | The new contraceptive revolution: developing innovative products outside of industry(†,‡) |
title_sort | new contraceptive revolution: developing innovative products outside of industry(†,‡) |
topic | Contraceptive Special Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401029/ https://www.ncbi.nlm.nih.gov/pubmed/32529250 http://dx.doi.org/10.1093/biolre/ioaa067 |
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