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Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity
The present study aimed to investigate the expression levels of C-X-C motif chemokine receptor 4 (CXCR4) and CXC ligand 12 (CXCL12) in patients with rheumatoid arthritis (RA) and the correlation with disease activity. In total, 60 patients with RA were selected as the study group, comprising of 28 p...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401245/ https://www.ncbi.nlm.nih.gov/pubmed/32782501 http://dx.doi.org/10.3892/etm.2020.8950 |
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author | Peng, Liping Zhu, Ning Mao, Jing Huang, Li Yang, Yameng Zhou, Zhengju Wang, Li Wu, Bin |
author_facet | Peng, Liping Zhu, Ning Mao, Jing Huang, Li Yang, Yameng Zhou, Zhengju Wang, Li Wu, Bin |
author_sort | Peng, Liping |
collection | PubMed |
description | The present study aimed to investigate the expression levels of C-X-C motif chemokine receptor 4 (CXCR4) and CXC ligand 12 (CXCL12) in patients with rheumatoid arthritis (RA) and the correlation with disease activity. In total, 60 patients with RA were selected as the study group, comprising of 28 patients in active-stage and 32 patients in remission-stage. In addition, 60 patients with osteoarthritis were selected as the control group. Western blotting and ELISA were used to detect the expression of CXCR4 and CXCL12, respectively. The Spearman's correlation test was used to analyze correlations between CXCR4 and CXCL12, and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), disease activity score 28 (DAS28) scores and rheumatoid factor (RF). The present results suggested that CXCR4 and CXCL12 expression levels in the serum and joint synovial fluid of the study group were significantly higher compared with the control group (P<0.05). Moreover, CXCR4 and CXCL12 expression levels in the RA-active group were higher compared with the remission (P<0.05) and control groups (P<0.01). The Pearson test results suggested that the expression levels of CXCR4 and CXCL12 in the serum and joint synovial fluid of patients with RA had a positive correlation with the ESR, CRP, RF and DAS28 scores (P<0.05). CXCL12 and CXCR4 were highly expressed in the serum and joint synovial fluid of patients with RA, and these expression levels were positively correlated with ESR, CRP, RF and DAS28 scores. Therefore, these clinical parameters may be used as indicators to evaluate the disease activity of patients with RA. |
format | Online Article Text |
id | pubmed-7401245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-74012452020-08-10 Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity Peng, Liping Zhu, Ning Mao, Jing Huang, Li Yang, Yameng Zhou, Zhengju Wang, Li Wu, Bin Exp Ther Med Articles The present study aimed to investigate the expression levels of C-X-C motif chemokine receptor 4 (CXCR4) and CXC ligand 12 (CXCL12) in patients with rheumatoid arthritis (RA) and the correlation with disease activity. In total, 60 patients with RA were selected as the study group, comprising of 28 patients in active-stage and 32 patients in remission-stage. In addition, 60 patients with osteoarthritis were selected as the control group. Western blotting and ELISA were used to detect the expression of CXCR4 and CXCL12, respectively. The Spearman's correlation test was used to analyze correlations between CXCR4 and CXCL12, and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), disease activity score 28 (DAS28) scores and rheumatoid factor (RF). The present results suggested that CXCR4 and CXCL12 expression levels in the serum and joint synovial fluid of the study group were significantly higher compared with the control group (P<0.05). Moreover, CXCR4 and CXCL12 expression levels in the RA-active group were higher compared with the remission (P<0.05) and control groups (P<0.01). The Pearson test results suggested that the expression levels of CXCR4 and CXCL12 in the serum and joint synovial fluid of patients with RA had a positive correlation with the ESR, CRP, RF and DAS28 scores (P<0.05). CXCL12 and CXCR4 were highly expressed in the serum and joint synovial fluid of patients with RA, and these expression levels were positively correlated with ESR, CRP, RF and DAS28 scores. Therefore, these clinical parameters may be used as indicators to evaluate the disease activity of patients with RA. D.A. Spandidos 2020-09 2020-06-26 /pmc/articles/PMC7401245/ /pubmed/32782501 http://dx.doi.org/10.3892/etm.2020.8950 Text en Copyright: © Peng et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Peng, Liping Zhu, Ning Mao, Jing Huang, Li Yang, Yameng Zhou, Zhengju Wang, Li Wu, Bin Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity |
title | Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity |
title_full | Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity |
title_fullStr | Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity |
title_full_unstemmed | Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity |
title_short | Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity |
title_sort | expression levels of cxcr4 and cxcl12 in patients with rheumatoid arthritis and its correlation with disease activity |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401245/ https://www.ncbi.nlm.nih.gov/pubmed/32782501 http://dx.doi.org/10.3892/etm.2020.8950 |
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