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Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration(†)

Efforts to develop new male or female nonhormonal, orally available contraceptives assume that to be effective and safe, targets must be (1) essential for fertility; (2) amenable to targeting by small-molecule inhibitors; and (3) restricted to the germline. In this perspective, we question the third...

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Detalles Bibliográficos
Autores principales: Balbach, Melanie, Fushimi, Makoto, Huggins, David J, Steegborn, Clemens, Meinke, Peter T, Levin, Lonny R, Buck, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401349/
https://www.ncbi.nlm.nih.gov/pubmed/32307523
http://dx.doi.org/10.1093/biolre/ioaa052
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author Balbach, Melanie
Fushimi, Makoto
Huggins, David J
Steegborn, Clemens
Meinke, Peter T
Levin, Lonny R
Buck, Jochen
author_facet Balbach, Melanie
Fushimi, Makoto
Huggins, David J
Steegborn, Clemens
Meinke, Peter T
Levin, Lonny R
Buck, Jochen
author_sort Balbach, Melanie
collection PubMed
description Efforts to develop new male or female nonhormonal, orally available contraceptives assume that to be effective and safe, targets must be (1) essential for fertility; (2) amenable to targeting by small-molecule inhibitors; and (3) restricted to the germline. In this perspective, we question the third assumption and propose that despite its wide expression, soluble adenylyl cyclase (sAC: ADCY10), which is essential for male fertility, is a valid target. We hypothesize that an acute-acting sAC inhibitor may provide orally available, on-demand, nonhormonal contraception for men without adverse, mechanism-based effects. To test this concept, we describe a collaboration between academia and the unique capabilities of a public-private drug discovery institute.
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spelling pubmed-74013492020-09-30 Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration(†) Balbach, Melanie Fushimi, Makoto Huggins, David J Steegborn, Clemens Meinke, Peter T Levin, Lonny R Buck, Jochen Biol Reprod Contraceptive Special Issue Efforts to develop new male or female nonhormonal, orally available contraceptives assume that to be effective and safe, targets must be (1) essential for fertility; (2) amenable to targeting by small-molecule inhibitors; and (3) restricted to the germline. In this perspective, we question the third assumption and propose that despite its wide expression, soluble adenylyl cyclase (sAC: ADCY10), which is essential for male fertility, is a valid target. We hypothesize that an acute-acting sAC inhibitor may provide orally available, on-demand, nonhormonal contraception for men without adverse, mechanism-based effects. To test this concept, we describe a collaboration between academia and the unique capabilities of a public-private drug discovery institute. Oxford University Press 2020-08 2020-04-20 /pmc/articles/PMC7401349/ /pubmed/32307523 http://dx.doi.org/10.1093/biolre/ioaa052 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Society for the Study of Reproduction. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Contraceptive Special Issue
Balbach, Melanie
Fushimi, Makoto
Huggins, David J
Steegborn, Clemens
Meinke, Peter T
Levin, Lonny R
Buck, Jochen
Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration(†)
title Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration(†)
title_full Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration(†)
title_fullStr Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration(†)
title_full_unstemmed Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration(†)
title_short Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration(†)
title_sort optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration(†)
topic Contraceptive Special Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401349/
https://www.ncbi.nlm.nih.gov/pubmed/32307523
http://dx.doi.org/10.1093/biolre/ioaa052
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