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Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis

WEE2 oocyte meiosis inhibiting kinase is a well-conserved oocyte specific kinase with a dual regulatory role during meiosis. Active WEE2 maintains immature, germinal vesicle stage oocytes in prophase I arrest prior to the luteinizing hormone surge and facilitates exit from metaphase II arrest at fer...

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Detalles Bibliográficos
Autores principales:	Hanna, Carol B, Mudaliar, Deepti, John, Kristen, Allen, C Leigh, Sun, Luxin, Hawkinson, Jon E, Schönbrunn, Ernst, Georg, Gunda I, Jensen, Jeffrey T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Contraceptive Special Issue
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401407/ https://www.ncbi.nlm.nih.gov/pubmed/32667031 http://dx.doi.org/10.1093/biolre/ioaa097

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