Cargando…
Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head
PURPOSE: To study the effect of changing heart rate on the ocular pulse and the dynamic biomechanical behavior of the optic nerve head (ONH) using a comprehensive mathematical model. METHODS: In a finite element model of a healthy eye, a biphasic choroid consisted of a solid phase with connective ti...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401455/ https://www.ncbi.nlm.nih.gov/pubmed/32315378 http://dx.doi.org/10.1167/iovs.61.4.27 |
_version_ | 1783566565398020096 |
---|---|
author | Jin, Yuejiao Wang, Xiaofei Irnadiastputri, Sylvi Febriana Rachmawati Mohan, Rosmin Elsa Aung, Tin Perera, Shamira A. Boote, Craig Jonas, Jost B. Schmetterer, Leopold Girard, Michaël J A. |
author_facet | Jin, Yuejiao Wang, Xiaofei Irnadiastputri, Sylvi Febriana Rachmawati Mohan, Rosmin Elsa Aung, Tin Perera, Shamira A. Boote, Craig Jonas, Jost B. Schmetterer, Leopold Girard, Michaël J A. |
author_sort | Jin, Yuejiao |
collection | PubMed |
description | PURPOSE: To study the effect of changing heart rate on the ocular pulse and the dynamic biomechanical behavior of the optic nerve head (ONH) using a comprehensive mathematical model. METHODS: In a finite element model of a healthy eye, a biphasic choroid consisted of a solid phase with connective tissues and a fluid phase with blood, and the lamina cribrosa (LC) was viscoelastic as characterized by a stress-relaxation test. We applied arterial pressures at 18 ocular entry sites (posterior ciliary arteries), and venous pressures at four exit sites (vortex veins). In the model, the heart rate was varied from 60 to 120 bpm (increment: 20 bpm). We assessed the ocular pulse amplitude (OPA), pulse volume, ONH deformations, and the dynamic modulus of the LC at different heart rates. RESULTS: With an increasing heart rate, the OPA decreased by 0.04 mm Hg for every 10 bpm increase in heart rate. The ocular pulse volume decreased linearly by 0.13 µL for every 10 bpm increase in heart rate. The storage modulus and the loss modulus of the LC increased by 0.014 and 0.04 MPa, respectively, for every 10 bpm increase in heart rate. CONCLUSIONS: In our model, the OPA, pulse volume, and ONH deformations decreased with an increasing heart rate, whereas the LC became stiffer. The effects of blood pressure/heart rate changes on ONH stiffening may be of interest for glaucoma pathology. |
format | Online Article Text |
id | pubmed-7401455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-74014552020-08-18 Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head Jin, Yuejiao Wang, Xiaofei Irnadiastputri, Sylvi Febriana Rachmawati Mohan, Rosmin Elsa Aung, Tin Perera, Shamira A. Boote, Craig Jonas, Jost B. Schmetterer, Leopold Girard, Michaël J A. Invest Ophthalmol Vis Sci Glaucoma PURPOSE: To study the effect of changing heart rate on the ocular pulse and the dynamic biomechanical behavior of the optic nerve head (ONH) using a comprehensive mathematical model. METHODS: In a finite element model of a healthy eye, a biphasic choroid consisted of a solid phase with connective tissues and a fluid phase with blood, and the lamina cribrosa (LC) was viscoelastic as characterized by a stress-relaxation test. We applied arterial pressures at 18 ocular entry sites (posterior ciliary arteries), and venous pressures at four exit sites (vortex veins). In the model, the heart rate was varied from 60 to 120 bpm (increment: 20 bpm). We assessed the ocular pulse amplitude (OPA), pulse volume, ONH deformations, and the dynamic modulus of the LC at different heart rates. RESULTS: With an increasing heart rate, the OPA decreased by 0.04 mm Hg for every 10 bpm increase in heart rate. The ocular pulse volume decreased linearly by 0.13 µL for every 10 bpm increase in heart rate. The storage modulus and the loss modulus of the LC increased by 0.014 and 0.04 MPa, respectively, for every 10 bpm increase in heart rate. CONCLUSIONS: In our model, the OPA, pulse volume, and ONH deformations decreased with an increasing heart rate, whereas the LC became stiffer. The effects of blood pressure/heart rate changes on ONH stiffening may be of interest for glaucoma pathology. The Association for Research in Vision and Ophthalmology 2020-04-21 /pmc/articles/PMC7401455/ /pubmed/32315378 http://dx.doi.org/10.1167/iovs.61.4.27 Text en Copyright 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Glaucoma Jin, Yuejiao Wang, Xiaofei Irnadiastputri, Sylvi Febriana Rachmawati Mohan, Rosmin Elsa Aung, Tin Perera, Shamira A. Boote, Craig Jonas, Jost B. Schmetterer, Leopold Girard, Michaël J A. Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head |
title | Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head |
title_full | Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head |
title_fullStr | Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head |
title_full_unstemmed | Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head |
title_short | Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head |
title_sort | effect of changing heart rate on the ocular pulse and dynamic biomechanical behavior of the optic nerve head |
topic | Glaucoma |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401455/ https://www.ncbi.nlm.nih.gov/pubmed/32315378 http://dx.doi.org/10.1167/iovs.61.4.27 |
work_keys_str_mv | AT jinyuejiao effectofchangingheartrateontheocularpulseanddynamicbiomechanicalbehavioroftheopticnervehead AT wangxiaofei effectofchangingheartrateontheocularpulseanddynamicbiomechanicalbehavioroftheopticnervehead AT irnadiastputrisylvifebrianarachmawati effectofchangingheartrateontheocularpulseanddynamicbiomechanicalbehavioroftheopticnervehead AT mohanrosminelsa effectofchangingheartrateontheocularpulseanddynamicbiomechanicalbehavioroftheopticnervehead AT aungtin effectofchangingheartrateontheocularpulseanddynamicbiomechanicalbehavioroftheopticnervehead AT pererashamiraa effectofchangingheartrateontheocularpulseanddynamicbiomechanicalbehavioroftheopticnervehead AT bootecraig effectofchangingheartrateontheocularpulseanddynamicbiomechanicalbehavioroftheopticnervehead AT jonasjostb effectofchangingheartrateontheocularpulseanddynamicbiomechanicalbehavioroftheopticnervehead AT schmettererleopold effectofchangingheartrateontheocularpulseanddynamicbiomechanicalbehavioroftheopticnervehead AT girardmichaelja effectofchangingheartrateontheocularpulseanddynamicbiomechanicalbehavioroftheopticnervehead |