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Diminished Cone Sensitivity in cpfl3 Mice Is Caused by Defective Transducin Signaling

PURPOSE: Cone photoreceptor function loss 3 (Gnat2(cpfl3/cpfl3) or cpfl3) is a mouse model commonly used as a functional cones null from a naturally occurring mutation in the α-subunit of cone transducin (Gnat2). We nevertheless detected robust cone-mediated light responses from cpfl3 animals, which...

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Detalles Bibliográficos
Autores principales:	Chen, Natalie S., Ingram, Norianne T., Frederiksen, Rikard, Sampath, Alapakkam P., Chen, Jeannie, Fain, Gordon L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Visual Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401474/ https://www.ncbi.nlm.nih.gov/pubmed/32315379 http://dx.doi.org/10.1167/iovs.61.4.26

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