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Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study

PURPOSE: To examine the 6-year incidence, progression, associated risk factors, and impact of myopic macular degeneration (MMD) in a myopic population in Singapore. METHODS: We examined myopic (spherical equivalent ≤–0.5 diopters) adults (N = 2157 persons and 3661 eyes) who were phakic at baseline a...

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Autores principales: Wong, Yee-Ling, Sabanayagam, Charumathi, Wong, Chee-Wai, Cheung, Yin-Bun, Man, Ryan Eyn Kidd, Yeo, Anna Chwee-Hong, Cheung, Gemmy, Chia, Audrey, Kuo, Anthony, Ang, Marcus, Ohno-Matsui, Kyoko, Wong, Tien-Yin, Wang, Jie Jin, Cheng, Ching-Yu, Hoang, Quan V., Lamoureux, Ecosse, Saw, Seang-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401489/
https://www.ncbi.nlm.nih.gov/pubmed/32298432
http://dx.doi.org/10.1167/iovs.61.4.14
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author Wong, Yee-Ling
Sabanayagam, Charumathi
Wong, Chee-Wai
Cheung, Yin-Bun
Man, Ryan Eyn Kidd
Yeo, Anna Chwee-Hong
Cheung, Gemmy
Chia, Audrey
Kuo, Anthony
Ang, Marcus
Ohno-Matsui, Kyoko
Wong, Tien-Yin
Wang, Jie Jin
Cheng, Ching-Yu
Hoang, Quan V.
Lamoureux, Ecosse
Saw, Seang-Mei
author_facet Wong, Yee-Ling
Sabanayagam, Charumathi
Wong, Chee-Wai
Cheung, Yin-Bun
Man, Ryan Eyn Kidd
Yeo, Anna Chwee-Hong
Cheung, Gemmy
Chia, Audrey
Kuo, Anthony
Ang, Marcus
Ohno-Matsui, Kyoko
Wong, Tien-Yin
Wang, Jie Jin
Cheng, Ching-Yu
Hoang, Quan V.
Lamoureux, Ecosse
Saw, Seang-Mei
author_sort Wong, Yee-Ling
collection PubMed
description PURPOSE: To examine the 6-year incidence, progression, associated risk factors, and impact of myopic macular degeneration (MMD) in a myopic population in Singapore. METHODS: We examined myopic (spherical equivalent ≤–0.5 diopters) adults (N = 2157 persons and 3661 eyes) who were phakic at baseline and participated in both baseline and 6-year follow-up visits of the Singapore Epidemiology of Eye Diseases study. Eye examinations, including visual acuity, subjective refraction and axial length (AL) measurements, were performed. MMD was graded from fundus photographs following the META-PM classification. Vision-related quality of life was assessed with Rasch-transformed scores from reading, mobility, and emotional domains of the Impact of Vision Impairment questionnaire. RESULTS: The 6-year eye-specific incidence of MMD among myopic eyes was 1.2% (95% CI, 0.9%–1.6%). Older age, worse spherical equivalent, and longer AL at baseline were associated with MMD incidence (all P < 0.001). The 6-year eye-specific progression of MMD in 288 eyes with baseline MMD was 17.0% (95% CI, 12.6%–21.4%). More severe MMD at baseline, worse spherical equivalent, and longer AL (all P < 0.05) were associated with MMD progression. Patients with Meta-PM categories 3 and 4 had worse best-corrected visual acuity and poorer vision-related quality of life outcomes than those without MMD (all P < 0.05). CONCLUSIONS: Over a 6-year period, one in 80 myopic eyes developed MMD and one in six with existing MMD had MMD progression. Myopia severity and AL were strong predictors of MMD development and progression. Eyes with severe MMD were at higher risk of MMD progression than those with less severe MMD, and were associated with poorer visual acuity and vision-related quality of life.
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spelling pubmed-74014892020-08-18 Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study Wong, Yee-Ling Sabanayagam, Charumathi Wong, Chee-Wai Cheung, Yin-Bun Man, Ryan Eyn Kidd Yeo, Anna Chwee-Hong Cheung, Gemmy Chia, Audrey Kuo, Anthony Ang, Marcus Ohno-Matsui, Kyoko Wong, Tien-Yin Wang, Jie Jin Cheng, Ching-Yu Hoang, Quan V. Lamoureux, Ecosse Saw, Seang-Mei Invest Ophthalmol Vis Sci Clinical and Epidemiologic Research PURPOSE: To examine the 6-year incidence, progression, associated risk factors, and impact of myopic macular degeneration (MMD) in a myopic population in Singapore. METHODS: We examined myopic (spherical equivalent ≤–0.5 diopters) adults (N = 2157 persons and 3661 eyes) who were phakic at baseline and participated in both baseline and 6-year follow-up visits of the Singapore Epidemiology of Eye Diseases study. Eye examinations, including visual acuity, subjective refraction and axial length (AL) measurements, were performed. MMD was graded from fundus photographs following the META-PM classification. Vision-related quality of life was assessed with Rasch-transformed scores from reading, mobility, and emotional domains of the Impact of Vision Impairment questionnaire. RESULTS: The 6-year eye-specific incidence of MMD among myopic eyes was 1.2% (95% CI, 0.9%–1.6%). Older age, worse spherical equivalent, and longer AL at baseline were associated with MMD incidence (all P < 0.001). The 6-year eye-specific progression of MMD in 288 eyes with baseline MMD was 17.0% (95% CI, 12.6%–21.4%). More severe MMD at baseline, worse spherical equivalent, and longer AL (all P < 0.05) were associated with MMD progression. Patients with Meta-PM categories 3 and 4 had worse best-corrected visual acuity and poorer vision-related quality of life outcomes than those without MMD (all P < 0.05). CONCLUSIONS: Over a 6-year period, one in 80 myopic eyes developed MMD and one in six with existing MMD had MMD progression. Myopia severity and AL were strong predictors of MMD development and progression. Eyes with severe MMD were at higher risk of MMD progression than those with less severe MMD, and were associated with poorer visual acuity and vision-related quality of life. The Association for Research in Vision and Ophthalmology 2020-04-16 /pmc/articles/PMC7401489/ /pubmed/32298432 http://dx.doi.org/10.1167/iovs.61.4.14 Text en Copyright 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Clinical and Epidemiologic Research
Wong, Yee-Ling
Sabanayagam, Charumathi
Wong, Chee-Wai
Cheung, Yin-Bun
Man, Ryan Eyn Kidd
Yeo, Anna Chwee-Hong
Cheung, Gemmy
Chia, Audrey
Kuo, Anthony
Ang, Marcus
Ohno-Matsui, Kyoko
Wong, Tien-Yin
Wang, Jie Jin
Cheng, Ching-Yu
Hoang, Quan V.
Lamoureux, Ecosse
Saw, Seang-Mei
Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study
title Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study
title_full Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study
title_fullStr Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study
title_full_unstemmed Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study
title_short Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study
title_sort six-year changes in myopic macular degeneration in adults of the singapore epidemiology of eye diseases study
topic Clinical and Epidemiologic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401489/
https://www.ncbi.nlm.nih.gov/pubmed/32298432
http://dx.doi.org/10.1167/iovs.61.4.14
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