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Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study
PURPOSE: To examine the 6-year incidence, progression, associated risk factors, and impact of myopic macular degeneration (MMD) in a myopic population in Singapore. METHODS: We examined myopic (spherical equivalent ≤–0.5 diopters) adults (N = 2157 persons and 3661 eyes) who were phakic at baseline a...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401489/ https://www.ncbi.nlm.nih.gov/pubmed/32298432 http://dx.doi.org/10.1167/iovs.61.4.14 |
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author | Wong, Yee-Ling Sabanayagam, Charumathi Wong, Chee-Wai Cheung, Yin-Bun Man, Ryan Eyn Kidd Yeo, Anna Chwee-Hong Cheung, Gemmy Chia, Audrey Kuo, Anthony Ang, Marcus Ohno-Matsui, Kyoko Wong, Tien-Yin Wang, Jie Jin Cheng, Ching-Yu Hoang, Quan V. Lamoureux, Ecosse Saw, Seang-Mei |
author_facet | Wong, Yee-Ling Sabanayagam, Charumathi Wong, Chee-Wai Cheung, Yin-Bun Man, Ryan Eyn Kidd Yeo, Anna Chwee-Hong Cheung, Gemmy Chia, Audrey Kuo, Anthony Ang, Marcus Ohno-Matsui, Kyoko Wong, Tien-Yin Wang, Jie Jin Cheng, Ching-Yu Hoang, Quan V. Lamoureux, Ecosse Saw, Seang-Mei |
author_sort | Wong, Yee-Ling |
collection | PubMed |
description | PURPOSE: To examine the 6-year incidence, progression, associated risk factors, and impact of myopic macular degeneration (MMD) in a myopic population in Singapore. METHODS: We examined myopic (spherical equivalent ≤–0.5 diopters) adults (N = 2157 persons and 3661 eyes) who were phakic at baseline and participated in both baseline and 6-year follow-up visits of the Singapore Epidemiology of Eye Diseases study. Eye examinations, including visual acuity, subjective refraction and axial length (AL) measurements, were performed. MMD was graded from fundus photographs following the META-PM classification. Vision-related quality of life was assessed with Rasch-transformed scores from reading, mobility, and emotional domains of the Impact of Vision Impairment questionnaire. RESULTS: The 6-year eye-specific incidence of MMD among myopic eyes was 1.2% (95% CI, 0.9%–1.6%). Older age, worse spherical equivalent, and longer AL at baseline were associated with MMD incidence (all P < 0.001). The 6-year eye-specific progression of MMD in 288 eyes with baseline MMD was 17.0% (95% CI, 12.6%–21.4%). More severe MMD at baseline, worse spherical equivalent, and longer AL (all P < 0.05) were associated with MMD progression. Patients with Meta-PM categories 3 and 4 had worse best-corrected visual acuity and poorer vision-related quality of life outcomes than those without MMD (all P < 0.05). CONCLUSIONS: Over a 6-year period, one in 80 myopic eyes developed MMD and one in six with existing MMD had MMD progression. Myopia severity and AL were strong predictors of MMD development and progression. Eyes with severe MMD were at higher risk of MMD progression than those with less severe MMD, and were associated with poorer visual acuity and vision-related quality of life. |
format | Online Article Text |
id | pubmed-7401489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-74014892020-08-18 Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study Wong, Yee-Ling Sabanayagam, Charumathi Wong, Chee-Wai Cheung, Yin-Bun Man, Ryan Eyn Kidd Yeo, Anna Chwee-Hong Cheung, Gemmy Chia, Audrey Kuo, Anthony Ang, Marcus Ohno-Matsui, Kyoko Wong, Tien-Yin Wang, Jie Jin Cheng, Ching-Yu Hoang, Quan V. Lamoureux, Ecosse Saw, Seang-Mei Invest Ophthalmol Vis Sci Clinical and Epidemiologic Research PURPOSE: To examine the 6-year incidence, progression, associated risk factors, and impact of myopic macular degeneration (MMD) in a myopic population in Singapore. METHODS: We examined myopic (spherical equivalent ≤–0.5 diopters) adults (N = 2157 persons and 3661 eyes) who were phakic at baseline and participated in both baseline and 6-year follow-up visits of the Singapore Epidemiology of Eye Diseases study. Eye examinations, including visual acuity, subjective refraction and axial length (AL) measurements, were performed. MMD was graded from fundus photographs following the META-PM classification. Vision-related quality of life was assessed with Rasch-transformed scores from reading, mobility, and emotional domains of the Impact of Vision Impairment questionnaire. RESULTS: The 6-year eye-specific incidence of MMD among myopic eyes was 1.2% (95% CI, 0.9%–1.6%). Older age, worse spherical equivalent, and longer AL at baseline were associated with MMD incidence (all P < 0.001). The 6-year eye-specific progression of MMD in 288 eyes with baseline MMD was 17.0% (95% CI, 12.6%–21.4%). More severe MMD at baseline, worse spherical equivalent, and longer AL (all P < 0.05) were associated with MMD progression. Patients with Meta-PM categories 3 and 4 had worse best-corrected visual acuity and poorer vision-related quality of life outcomes than those without MMD (all P < 0.05). CONCLUSIONS: Over a 6-year period, one in 80 myopic eyes developed MMD and one in six with existing MMD had MMD progression. Myopia severity and AL were strong predictors of MMD development and progression. Eyes with severe MMD were at higher risk of MMD progression than those with less severe MMD, and were associated with poorer visual acuity and vision-related quality of life. The Association for Research in Vision and Ophthalmology 2020-04-16 /pmc/articles/PMC7401489/ /pubmed/32298432 http://dx.doi.org/10.1167/iovs.61.4.14 Text en Copyright 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Clinical and Epidemiologic Research Wong, Yee-Ling Sabanayagam, Charumathi Wong, Chee-Wai Cheung, Yin-Bun Man, Ryan Eyn Kidd Yeo, Anna Chwee-Hong Cheung, Gemmy Chia, Audrey Kuo, Anthony Ang, Marcus Ohno-Matsui, Kyoko Wong, Tien-Yin Wang, Jie Jin Cheng, Ching-Yu Hoang, Quan V. Lamoureux, Ecosse Saw, Seang-Mei Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study |
title | Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study |
title_full | Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study |
title_fullStr | Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study |
title_full_unstemmed | Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study |
title_short | Six-Year Changes in Myopic Macular Degeneration in Adults of the Singapore Epidemiology of Eye Diseases Study |
title_sort | six-year changes in myopic macular degeneration in adults of the singapore epidemiology of eye diseases study |
topic | Clinical and Epidemiologic Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401489/ https://www.ncbi.nlm.nih.gov/pubmed/32298432 http://dx.doi.org/10.1167/iovs.61.4.14 |
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