Corneal Nerve Ablation Abolishes Ocular Immune Privilege by Downregulating CD103 on T Regulatory Cells

PURPOSE: Severing corneal nerves during orthotopic corneal transplantation elicits the elaboration of the neuropeptide substance P (SP), which induces the generation of CD11c(+) contrasuppressor (CS) cells. CS cells disable T regulatory cells (Tregs) that are induced when antigens enter the anterior...

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Detalles Bibliográficos
Autores principales: Neelam, Sudha, Niederkorn, Jerry Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Immunology and Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401639/
https://www.ncbi.nlm.nih.gov/pubmed/32305043
http://dx.doi.org/10.1167/iovs.61.4.25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401639/
https://www.ncbi.nlm.nih.gov/pubmed/32305043
http://dx.doi.org/10.1167/iovs.61.4.25

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