Evaluation of Oral Administration of Lactobacillus plantarum CAM6 Strain as an Alternative to Antibiotics in Weaned Pigs

SIMPLE SUMMARY: Currently, due to intensive production, pigs are weaned early, which generates stress due to separation from the sow, metabolic disorders, and decreased productive performance. Thus, sub-therapeutic antibiotics have been used to alleviate these detrimental effects; however, it has been shown that these practices create microbial resistance and cross-resistance to other microorganisms. Although the European Union banned antibiotic growth promoters (AGP), many countries in the world still use them widely. In the present study, oral administration of Lactobacillus plantarum CAM6 in weaned pigs improved productive performance from the second experimental week and increased total serum levels of IgA without causing adverse effects on health indicators and acid-base balance. These results suggest this probiotic bacterium can be used as an alternative to antibiotics in weaned pigs. ABSTRACT: The objective was to evaluate the effect of oral administration of Lactobacillus plantarum CAM6 strain as an alternative to antibiotics in weaned pigs on productive parameters, blood biochemical profile, and IgA serum levels. Thirty-six 21-day-old weaned piglets were randomly assigned to three groups with three replicates of four piglets each. Treatments consisted of a basal diet (BD; T0) without probiotics or antibiotics; BD + antibiotics and the same basal diet used in T0 plus oral administration of 5 mL × 10(9) CFU/mL of L. plantarum CAM-6 (T2). During the study (21 to 49 days of age) T2 obtained a similar live weight, weight gain, and feed conversion ratio when compared to the T1. Both treatments were better in these variables compared to T0 (p ≤ 0.05). Furthermore, T2 increased serum IgA levels (p ≤ 0.05). Additionally, hematological parameters and acid-base balance remained similar in all groups. However, significant reductions in the mean corpuscular hemoglobin concentration, platelets, and metabolic hydrogen ions were observed in T1 (p ≤ 0.05). The results of this study suggest that supplementation with L. plantarum CAM6 can be an alternative to antibiotics. Studies to evaluate its efficacy under commercial conditions and water administration require further evaluation.