Cargando…

Distribution, Metabolism, and Recovery of Resin Acids in the Intestine and Tissues of Broiler Chickens in a Feeding Trial With Tall Oil Fatty Acid-Supplemented Diets

Tall oil fatty acids (TOFA) are novel, health-improving feed ingredients which have been shown to improve the performance of broiler chickens. TOFA contains resin acids, the suggested key components for its beneficial effects. For product safety, possible accumulation of TOFA components in tissues c...

Descripción completa

Detalles Bibliográficos
Autores principales: Apajalahti, Juha, Vienola, Kirsi, Raatikainen, Kari, Kettunen, Hannele, Vuorenmaa, Juhani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401731/
https://www.ncbi.nlm.nih.gov/pubmed/32851020
http://dx.doi.org/10.3389/fvets.2020.00437
_version_ 1783566618777878528
author Apajalahti, Juha
Vienola, Kirsi
Raatikainen, Kari
Kettunen, Hannele
Vuorenmaa, Juhani
author_facet Apajalahti, Juha
Vienola, Kirsi
Raatikainen, Kari
Kettunen, Hannele
Vuorenmaa, Juhani
author_sort Apajalahti, Juha
collection PubMed
description Tall oil fatty acids (TOFA) are novel, health-improving feed ingredients which have been shown to improve the performance of broiler chickens. TOFA contains resin acids, the suggested key components for its beneficial effects. For product safety, possible accumulation of TOFA components in tissues consumed by end-users is an issue of major importance. Wheat-soy-based diets with an indigestible marker and TOFA at 0, 750 and 3,000 g/t were fed to broiler chickens for 5 weeks; 11 replicate pens/treatment. Deposition of resin acids was assessed by analyzing jejunal tissue, breast muscle, abdominal fat, blood, liver, bile, and digesta along the intestinal tract at the end of the 35-day trial. Both free and conjugated resin acids were quantified. With TOFA 3,000 g/t diet, 30% of ingested resin acids could not be recovered from jejunal digesta. Also, a proportion representing 45% of resin acids fed were in conjugated form and thus had already re-entered the intestine from the bile duct. This means that at least 75% of resin acids ingested had become absorbed in, or proximal to jejunum. Recovery of resin acids in excreta was 45 and 70% when TOFA was fed at 750 and 3,000 g/t, respectively. Based on recovery data, of the estimated 1,087 mg of resin acids ingested by birds on the high TOFA dose during their lifetime, about 330 mg was unaccounted for. In analysis of jejunal tissue, blood, liver, bile, breast muscle, and abdominal tissue, <1 mg of resin acids was found after the 35-day trial when TOFA at the 4-fold the recommended dose was fed. It is likely that the host or microbiota mineralized or converted one-third of resin acids to a form that escaped analysis. TOFA at 3,000 g/t dose caused no detectable adverse effects in broiler chickens. Based on analysis of breast meat and liver, the common edible tissues, a human consumer would ingest <100 μg of resin acids in a single meal. That is one-thousandth of the dose shown to be harmless in rodents. Thus, unintentional exposure of human consumers to resin acids is marginal, and posed no safety concerns.
format Online
Article
Text
id pubmed-7401731
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-74017312020-08-25 Distribution, Metabolism, and Recovery of Resin Acids in the Intestine and Tissues of Broiler Chickens in a Feeding Trial With Tall Oil Fatty Acid-Supplemented Diets Apajalahti, Juha Vienola, Kirsi Raatikainen, Kari Kettunen, Hannele Vuorenmaa, Juhani Front Vet Sci Veterinary Science Tall oil fatty acids (TOFA) are novel, health-improving feed ingredients which have been shown to improve the performance of broiler chickens. TOFA contains resin acids, the suggested key components for its beneficial effects. For product safety, possible accumulation of TOFA components in tissues consumed by end-users is an issue of major importance. Wheat-soy-based diets with an indigestible marker and TOFA at 0, 750 and 3,000 g/t were fed to broiler chickens for 5 weeks; 11 replicate pens/treatment. Deposition of resin acids was assessed by analyzing jejunal tissue, breast muscle, abdominal fat, blood, liver, bile, and digesta along the intestinal tract at the end of the 35-day trial. Both free and conjugated resin acids were quantified. With TOFA 3,000 g/t diet, 30% of ingested resin acids could not be recovered from jejunal digesta. Also, a proportion representing 45% of resin acids fed were in conjugated form and thus had already re-entered the intestine from the bile duct. This means that at least 75% of resin acids ingested had become absorbed in, or proximal to jejunum. Recovery of resin acids in excreta was 45 and 70% when TOFA was fed at 750 and 3,000 g/t, respectively. Based on recovery data, of the estimated 1,087 mg of resin acids ingested by birds on the high TOFA dose during their lifetime, about 330 mg was unaccounted for. In analysis of jejunal tissue, blood, liver, bile, breast muscle, and abdominal tissue, <1 mg of resin acids was found after the 35-day trial when TOFA at the 4-fold the recommended dose was fed. It is likely that the host or microbiota mineralized or converted one-third of resin acids to a form that escaped analysis. TOFA at 3,000 g/t dose caused no detectable adverse effects in broiler chickens. Based on analysis of breast meat and liver, the common edible tissues, a human consumer would ingest <100 μg of resin acids in a single meal. That is one-thousandth of the dose shown to be harmless in rodents. Thus, unintentional exposure of human consumers to resin acids is marginal, and posed no safety concerns. Frontiers Media S.A. 2020-07-28 /pmc/articles/PMC7401731/ /pubmed/32851020 http://dx.doi.org/10.3389/fvets.2020.00437 Text en Copyright © 2020 Apajalahti, Vienola, Raatikainen, Kettunen and Vuorenmaa. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Apajalahti, Juha
Vienola, Kirsi
Raatikainen, Kari
Kettunen, Hannele
Vuorenmaa, Juhani
Distribution, Metabolism, and Recovery of Resin Acids in the Intestine and Tissues of Broiler Chickens in a Feeding Trial With Tall Oil Fatty Acid-Supplemented Diets
title Distribution, Metabolism, and Recovery of Resin Acids in the Intestine and Tissues of Broiler Chickens in a Feeding Trial With Tall Oil Fatty Acid-Supplemented Diets
title_full Distribution, Metabolism, and Recovery of Resin Acids in the Intestine and Tissues of Broiler Chickens in a Feeding Trial With Tall Oil Fatty Acid-Supplemented Diets
title_fullStr Distribution, Metabolism, and Recovery of Resin Acids in the Intestine and Tissues of Broiler Chickens in a Feeding Trial With Tall Oil Fatty Acid-Supplemented Diets
title_full_unstemmed Distribution, Metabolism, and Recovery of Resin Acids in the Intestine and Tissues of Broiler Chickens in a Feeding Trial With Tall Oil Fatty Acid-Supplemented Diets
title_short Distribution, Metabolism, and Recovery of Resin Acids in the Intestine and Tissues of Broiler Chickens in a Feeding Trial With Tall Oil Fatty Acid-Supplemented Diets
title_sort distribution, metabolism, and recovery of resin acids in the intestine and tissues of broiler chickens in a feeding trial with tall oil fatty acid-supplemented diets
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401731/
https://www.ncbi.nlm.nih.gov/pubmed/32851020
http://dx.doi.org/10.3389/fvets.2020.00437
work_keys_str_mv AT apajalahtijuha distributionmetabolismandrecoveryofresinacidsintheintestineandtissuesofbroilerchickensinafeedingtrialwithtalloilfattyacidsupplementeddiets
AT vienolakirsi distributionmetabolismandrecoveryofresinacidsintheintestineandtissuesofbroilerchickensinafeedingtrialwithtalloilfattyacidsupplementeddiets
AT raatikainenkari distributionmetabolismandrecoveryofresinacidsintheintestineandtissuesofbroilerchickensinafeedingtrialwithtalloilfattyacidsupplementeddiets
AT kettunenhannele distributionmetabolismandrecoveryofresinacidsintheintestineandtissuesofbroilerchickensinafeedingtrialwithtalloilfattyacidsupplementeddiets
AT vuorenmaajuhani distributionmetabolismandrecoveryofresinacidsintheintestineandtissuesofbroilerchickensinafeedingtrialwithtalloilfattyacidsupplementeddiets