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Rashomon at the kinetochore: Function(s) of the Mad1–cyclin B1 complex

In the film Rashomon, four witnesses describe seemingly contradictory views of one event. In a recent analogy, an interaction between the master mitotic regulator cyclin B1 and the spindle checkpoint component Mad1 was independently described by three groups who propose strikingly different function...

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Detalles Bibliográficos
Autores principales: Houston, Jack, Lara-Gonzalez, Pablo, Desai, Arshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401815/
https://www.ncbi.nlm.nih.gov/pubmed/32614383
http://dx.doi.org/10.1083/jcb.202006006
Descripción
Sumario:In the film Rashomon, four witnesses describe seemingly contradictory views of one event. In a recent analogy, an interaction between the master mitotic regulator cyclin B1 and the spindle checkpoint component Mad1 was independently described by three groups who propose strikingly different functions for this interaction. Here, we summarize their findings and present a perspective on reconciling the different views.