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Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus
PURPOSE: To investigate the clinical significance of the changes in the macular microvasculature in patients with diabetes mellitus type 2 without diabetic retinopathy. METHODS: Fifty-five patients with diabetes mellitus type 2 without diabetic retinopathy and 48 healthy individuals were enrolled in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401845/ https://www.ncbi.nlm.nih.gov/pubmed/32150245 http://dx.doi.org/10.1167/iovs.61.3.4 |
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author | Choi, Eun Young Park, Sung Eun Lee, Sung Chul Koh, Hyoung Jun Kim, Sung Soo Byeon, Suk Ho Kim, Min |
author_facet | Choi, Eun Young Park, Sung Eun Lee, Sung Chul Koh, Hyoung Jun Kim, Sung Soo Byeon, Suk Ho Kim, Min |
author_sort | Choi, Eun Young |
collection | PubMed |
description | PURPOSE: To investigate the clinical significance of the changes in the macular microvasculature in patients with diabetes mellitus type 2 without diabetic retinopathy. METHODS: Fifty-five patients with diabetes mellitus type 2 without diabetic retinopathy and 48 healthy individuals were enrolled in a prospective cross-sectional study. We identified the changes of optical coherence tomography angiography parameters (foveal avascular zone [FAZ] area and circularity, vessel density, and perfusion index) of the 6 × 6-mm macular scan. Correlation and multiple regression analyses were performed between optical coherence tomography angiography parameters and previously known diabetes mellitus type 2-related demographic and systemic characteristics, and serum biochemical markers. RESULTS: FAZ parameters and perfusion index of the superficial and deep vascular plexus showed significant correlation with serum insulin level, and homeostasis model assessment indices. In multiple linear regression analysis, low insulin levels predicted increased FAZ areas in both the superficial (β = –0.007; P = 0.030) and deep layers (β = –0.010; P = 0.018) and a decreased perfusion index in the deep layer (β = 0.003; P = 0.001). CONCLUSIONS: The expansion and loss of circularity of the FAZ and the decrease in the perfusion index may be affected by insulin resistance and secretory capacity in patients with diabetes mellitus type 2 with no diabetic retinopathy. |
format | Online Article Text |
id | pubmed-7401845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-74018452020-08-19 Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus Choi, Eun Young Park, Sung Eun Lee, Sung Chul Koh, Hyoung Jun Kim, Sung Soo Byeon, Suk Ho Kim, Min Invest Ophthalmol Vis Sci Retina PURPOSE: To investigate the clinical significance of the changes in the macular microvasculature in patients with diabetes mellitus type 2 without diabetic retinopathy. METHODS: Fifty-five patients with diabetes mellitus type 2 without diabetic retinopathy and 48 healthy individuals were enrolled in a prospective cross-sectional study. We identified the changes of optical coherence tomography angiography parameters (foveal avascular zone [FAZ] area and circularity, vessel density, and perfusion index) of the 6 × 6-mm macular scan. Correlation and multiple regression analyses were performed between optical coherence tomography angiography parameters and previously known diabetes mellitus type 2-related demographic and systemic characteristics, and serum biochemical markers. RESULTS: FAZ parameters and perfusion index of the superficial and deep vascular plexus showed significant correlation with serum insulin level, and homeostasis model assessment indices. In multiple linear regression analysis, low insulin levels predicted increased FAZ areas in both the superficial (β = –0.007; P = 0.030) and deep layers (β = –0.010; P = 0.018) and a decreased perfusion index in the deep layer (β = 0.003; P = 0.001). CONCLUSIONS: The expansion and loss of circularity of the FAZ and the decrease in the perfusion index may be affected by insulin resistance and secretory capacity in patients with diabetes mellitus type 2 with no diabetic retinopathy. The Association for Research in Vision and Ophthalmology 2020-03-09 /pmc/articles/PMC7401845/ /pubmed/32150245 http://dx.doi.org/10.1167/iovs.61.3.4 Text en Copyright 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Retina Choi, Eun Young Park, Sung Eun Lee, Sung Chul Koh, Hyoung Jun Kim, Sung Soo Byeon, Suk Ho Kim, Min Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus |
title | Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus |
title_full | Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus |
title_fullStr | Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus |
title_full_unstemmed | Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus |
title_short | Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus |
title_sort | association between clinical biomarkers and optical coherence tomography angiography parameters in type 2 diabetes mellitus |
topic | Retina |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401845/ https://www.ncbi.nlm.nih.gov/pubmed/32150245 http://dx.doi.org/10.1167/iovs.61.3.4 |
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