In Vivo CRISPR/Cas9-Mediated Genome Editing Mitigates Photoreceptor Degeneration in a Mouse Model of X-Linked Retinitis Pigmentosa

PURPOSE: Retinitis pigmentosa GTPase regulator (RPGR)-related X-linked retinitis pigmentosa is associated with one of the most severe phenotypes among inherited retinal disease. The aim of this study was to investigate Clustered Regularly Interspaced Short Palindromic Repeat/Cas9-mediated gene editi...

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Detalles Bibliográficos
Autores principales: Hu, Shuang, Du, Juan, Chen, Ningning, Jia, Ruixuan, Zhang, Jinlu, Liu, Xiaozhen, Yang, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401909/
https://www.ncbi.nlm.nih.gov/pubmed/32330228
http://dx.doi.org/10.1167/iovs.61.4.31

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