The SARS-CoV-2 Nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

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The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the ~30 kb viral RNA genome to aid its packaging into the 80–90nm membrane-enveloped virion. The N protein is composed of N-terminal RNA-binding and C-terminal dimerization domains that are flanked by three intrinsically disordered reg...

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Detalles Bibliográficos
Autores principales: Lu, Shan, Ye, Qiaozhen, Singh, Digvijay, Villa, Elizabeth, Cleveland, Don W., Corbett, Kevin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402048/
https://www.ncbi.nlm.nih.gov/pubmed/32766587
http://dx.doi.org/10.1101/2020.07.30.228023
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