Cargando…

Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders

Neurodegenerative disorders have emerged as a serious health issue in the current era. The most common neurodegenerative disorders are Alzheimer’s disease (AD), Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS). These diseases involve progressive impairment of neurodeg...

Descripción completa

Detalles Bibliográficos
Autores principales: Khan, Amjad, Ikram, Muhammad, Hahm, Jong Ryeal, Kim, Myeong Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402130/
https://www.ncbi.nlm.nih.gov/pubmed/32664395
http://dx.doi.org/10.3390/antiox9070609
_version_ 1783566695566147584
author Khan, Amjad
Ikram, Muhammad
Hahm, Jong Ryeal
Kim, Myeong Ok
author_facet Khan, Amjad
Ikram, Muhammad
Hahm, Jong Ryeal
Kim, Myeong Ok
author_sort Khan, Amjad
collection PubMed
description Neurodegenerative disorders have emerged as a serious health issue in the current era. The most common neurodegenerative disorders are Alzheimer’s disease (AD), Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS). These diseases involve progressive impairment of neurodegeneration and memory impairment. A wide range of compounds have been identified as potential neuroprotective agents against different models of neurodegeneration both in vivo and in vitro. Hesperetin, a flavanone class of citrus flavonoid, is a derivative of hesperidin found in citrus fruits such as oranges, grapes, and lemons. It has been extensively reported that hesperetin exerts neuroprotective effects in experimental models of neurodegenerative diseases. In this systematic review, we have compiled all the studies conducted on hesperetin in both in vivo and in vitro models of neurodegeneration. Here, we have used an approach to lessen the bias in each study, providing a least biased, broad understanding of findings and impartial conclusions of the strength of evidence and the reliability of findings. In this review, we collected different papers from a wide range of journals describing the beneficial effects of hesperetin on animal models of neurodegeneration. Our results demonstrated consistent neuroprotective effects of hesperetin against different models of neurodegeneration. In addition, we have summarized its underlying mechanisms. This study provides the foundations for future studies and recommendations of further mechanistic approaches to conduct preclinical studies on hesperetin in different models.
format Online
Article
Text
id pubmed-7402130
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74021302020-08-07 Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders Khan, Amjad Ikram, Muhammad Hahm, Jong Ryeal Kim, Myeong Ok Antioxidants (Basel) Review Neurodegenerative disorders have emerged as a serious health issue in the current era. The most common neurodegenerative disorders are Alzheimer’s disease (AD), Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS). These diseases involve progressive impairment of neurodegeneration and memory impairment. A wide range of compounds have been identified as potential neuroprotective agents against different models of neurodegeneration both in vivo and in vitro. Hesperetin, a flavanone class of citrus flavonoid, is a derivative of hesperidin found in citrus fruits such as oranges, grapes, and lemons. It has been extensively reported that hesperetin exerts neuroprotective effects in experimental models of neurodegenerative diseases. In this systematic review, we have compiled all the studies conducted on hesperetin in both in vivo and in vitro models of neurodegeneration. Here, we have used an approach to lessen the bias in each study, providing a least biased, broad understanding of findings and impartial conclusions of the strength of evidence and the reliability of findings. In this review, we collected different papers from a wide range of journals describing the beneficial effects of hesperetin on animal models of neurodegeneration. Our results demonstrated consistent neuroprotective effects of hesperetin against different models of neurodegeneration. In addition, we have summarized its underlying mechanisms. This study provides the foundations for future studies and recommendations of further mechanistic approaches to conduct preclinical studies on hesperetin in different models. MDPI 2020-07-10 /pmc/articles/PMC7402130/ /pubmed/32664395 http://dx.doi.org/10.3390/antiox9070609 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khan, Amjad
Ikram, Muhammad
Hahm, Jong Ryeal
Kim, Myeong Ok
Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders
title Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders
title_full Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders
title_fullStr Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders
title_full_unstemmed Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders
title_short Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders
title_sort antioxidant and anti-inflammatory effects of citrus flavonoid hesperetin: special focus on neurological disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402130/
https://www.ncbi.nlm.nih.gov/pubmed/32664395
http://dx.doi.org/10.3390/antiox9070609
work_keys_str_mv AT khanamjad antioxidantandantiinflammatoryeffectsofcitrusflavonoidhesperetinspecialfocusonneurologicaldisorders
AT ikrammuhammad antioxidantandantiinflammatoryeffectsofcitrusflavonoidhesperetinspecialfocusonneurologicaldisorders
AT hahmjongryeal antioxidantandantiinflammatoryeffectsofcitrusflavonoidhesperetinspecialfocusonneurologicaldisorders
AT kimmyeongok antioxidantandantiinflammatoryeffectsofcitrusflavonoidhesperetinspecialfocusonneurologicaldisorders