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Modeling the transmission dynamics of the COVID-19 Pandemic in South Africa
Since its emergence late in 2019, the COVID-19 pandemic continues to exude major public health and socio-economic burden globally. South Africa is currently the epicenter for the pandemic in Africa. This study is based on the use of a compartmental model to analyze the transmission dynamics of the d...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402282/ https://www.ncbi.nlm.nih.gov/pubmed/32763338 http://dx.doi.org/10.1016/j.mbs.2020.108441 |
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author | Garba, Salisu M. Lubuma, Jean M.-S. Tsanou, Berge |
author_facet | Garba, Salisu M. Lubuma, Jean M.-S. Tsanou, Berge |
author_sort | Garba, Salisu M. |
collection | PubMed |
description | Since its emergence late in 2019, the COVID-19 pandemic continues to exude major public health and socio-economic burden globally. South Africa is currently the epicenter for the pandemic in Africa. This study is based on the use of a compartmental model to analyze the transmission dynamics of the disease in South Africa. A notable feature of the model is the incorporation of the role of environmental contamination by COVID-infected individuals. The model, which is fitted and parametrized using cumulative mortality data from South Africa, is used to assess the impact of various control and mitigation strategies. Rigorous analysis of the model reveals that its associated continuum of disease-free equilibria is globally-asymptotically stable whenever the control reproduction number is less than unity. The epidemiological implication of this result is that the disease will eventually die out, particularly if control measures are implemented early and for a sustainable period of time. For instance, numerical simulations suggest that if the lockdown measures in South Africa were implemented a week later than the 26 March, 2020 date it was implemented, this will result in the extension of the predicted peak time of the pandemic, and causing about 10% more cumulative deaths. In addition to illustrating the effectiveness of self-isolation in reducing the number of cases, our study emphasizes the importance of surveillance testing and contact tracing of the contacts and confirmed cases in curtailing the pandemic in South Africa. |
format | Online Article Text |
id | pubmed-7402282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74022822020-08-05 Modeling the transmission dynamics of the COVID-19 Pandemic in South Africa Garba, Salisu M. Lubuma, Jean M.-S. Tsanou, Berge Math Biosci Article Since its emergence late in 2019, the COVID-19 pandemic continues to exude major public health and socio-economic burden globally. South Africa is currently the epicenter for the pandemic in Africa. This study is based on the use of a compartmental model to analyze the transmission dynamics of the disease in South Africa. A notable feature of the model is the incorporation of the role of environmental contamination by COVID-infected individuals. The model, which is fitted and parametrized using cumulative mortality data from South Africa, is used to assess the impact of various control and mitigation strategies. Rigorous analysis of the model reveals that its associated continuum of disease-free equilibria is globally-asymptotically stable whenever the control reproduction number is less than unity. The epidemiological implication of this result is that the disease will eventually die out, particularly if control measures are implemented early and for a sustainable period of time. For instance, numerical simulations suggest that if the lockdown measures in South Africa were implemented a week later than the 26 March, 2020 date it was implemented, this will result in the extension of the predicted peak time of the pandemic, and causing about 10% more cumulative deaths. In addition to illustrating the effectiveness of self-isolation in reducing the number of cases, our study emphasizes the importance of surveillance testing and contact tracing of the contacts and confirmed cases in curtailing the pandemic in South Africa. Elsevier Inc. 2020-10 2020-08-04 /pmc/articles/PMC7402282/ /pubmed/32763338 http://dx.doi.org/10.1016/j.mbs.2020.108441 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Garba, Salisu M. Lubuma, Jean M.-S. Tsanou, Berge Modeling the transmission dynamics of the COVID-19 Pandemic in South Africa |
title | Modeling the transmission dynamics of the COVID-19 Pandemic in South Africa |
title_full | Modeling the transmission dynamics of the COVID-19 Pandemic in South Africa |
title_fullStr | Modeling the transmission dynamics of the COVID-19 Pandemic in South Africa |
title_full_unstemmed | Modeling the transmission dynamics of the COVID-19 Pandemic in South Africa |
title_short | Modeling the transmission dynamics of the COVID-19 Pandemic in South Africa |
title_sort | modeling the transmission dynamics of the covid-19 pandemic in south africa |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402282/ https://www.ncbi.nlm.nih.gov/pubmed/32763338 http://dx.doi.org/10.1016/j.mbs.2020.108441 |
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