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Bone Regeneration Capability of 3D Printed Ceramic Scaffolds

In this study, we evaluated the bone regenerative capability of a customizable hydroxyapatite (HA) and tricalcium phosphate (TCP) scaffold using a digital light processing (DLP)-type 3D printing system. Twelve healthy adult male beagle dogs were the study subjects. A total of 48 defects were created...

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Autores principales: Kim, Ju-Won, Yang, Byoung-Eun, Hong, Seok-Jin, Choi, Hyo-Geun, Byeon, Sun-Ju, Lim, Ho-Kyung, Chung, Sung-Min, Lee, Jong-Ho, Byun, Soo-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402304/
https://www.ncbi.nlm.nih.gov/pubmed/32650589
http://dx.doi.org/10.3390/ijms21144837
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author Kim, Ju-Won
Yang, Byoung-Eun
Hong, Seok-Jin
Choi, Hyo-Geun
Byeon, Sun-Ju
Lim, Ho-Kyung
Chung, Sung-Min
Lee, Jong-Ho
Byun, Soo-Hwan
author_facet Kim, Ju-Won
Yang, Byoung-Eun
Hong, Seok-Jin
Choi, Hyo-Geun
Byeon, Sun-Ju
Lim, Ho-Kyung
Chung, Sung-Min
Lee, Jong-Ho
Byun, Soo-Hwan
author_sort Kim, Ju-Won
collection PubMed
description In this study, we evaluated the bone regenerative capability of a customizable hydroxyapatite (HA) and tricalcium phosphate (TCP) scaffold using a digital light processing (DLP)-type 3D printing system. Twelve healthy adult male beagle dogs were the study subjects. A total of 48 defects were created, with two defects on each side of the mandible in all the dogs. The defect sites in the negative control group (sixteen defects) were left untreated (the NS group), whereas those in the positive control group (sixteen defects) were filled with a particle-type substitute (the PS group). The defect sites in the experimental groups (sixteen defects) were filled with a 3D printed substitute (the 3DS group). Six dogs each were exterminated after healing periods of 4 and 8 weeks. Radiological and histomorphometrical evaluations were then performed. None of the groups showed any specific problems. In radiological evaluation, there was a significant difference in the amount of new bone formation after 4 weeks (p < 0.05) between the PS and 3DS groups. For both of the evaluations, the difference in the total amount of bone after 8 weeks was statistically significant (p < 0.05). There was no statistically significant difference in new bone between the PS and 3DS groups in both evaluations after 8 weeks (p > 0.05). The proposed HA/TCP scaffold without polymers, obtained using the DLP-type 3D printing system, can be applied for bone regeneration. The 3D printing of a HA/TCP scaffold without polymers can be used for fabricating customized bone grafting substitutes.
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spelling pubmed-74023042020-08-11 Bone Regeneration Capability of 3D Printed Ceramic Scaffolds Kim, Ju-Won Yang, Byoung-Eun Hong, Seok-Jin Choi, Hyo-Geun Byeon, Sun-Ju Lim, Ho-Kyung Chung, Sung-Min Lee, Jong-Ho Byun, Soo-Hwan Int J Mol Sci Article In this study, we evaluated the bone regenerative capability of a customizable hydroxyapatite (HA) and tricalcium phosphate (TCP) scaffold using a digital light processing (DLP)-type 3D printing system. Twelve healthy adult male beagle dogs were the study subjects. A total of 48 defects were created, with two defects on each side of the mandible in all the dogs. The defect sites in the negative control group (sixteen defects) were left untreated (the NS group), whereas those in the positive control group (sixteen defects) were filled with a particle-type substitute (the PS group). The defect sites in the experimental groups (sixteen defects) were filled with a 3D printed substitute (the 3DS group). Six dogs each were exterminated after healing periods of 4 and 8 weeks. Radiological and histomorphometrical evaluations were then performed. None of the groups showed any specific problems. In radiological evaluation, there was a significant difference in the amount of new bone formation after 4 weeks (p < 0.05) between the PS and 3DS groups. For both of the evaluations, the difference in the total amount of bone after 8 weeks was statistically significant (p < 0.05). There was no statistically significant difference in new bone between the PS and 3DS groups in both evaluations after 8 weeks (p > 0.05). The proposed HA/TCP scaffold without polymers, obtained using the DLP-type 3D printing system, can be applied for bone regeneration. The 3D printing of a HA/TCP scaffold without polymers can be used for fabricating customized bone grafting substitutes. MDPI 2020-07-08 /pmc/articles/PMC7402304/ /pubmed/32650589 http://dx.doi.org/10.3390/ijms21144837 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Ju-Won
Yang, Byoung-Eun
Hong, Seok-Jin
Choi, Hyo-Geun
Byeon, Sun-Ju
Lim, Ho-Kyung
Chung, Sung-Min
Lee, Jong-Ho
Byun, Soo-Hwan
Bone Regeneration Capability of 3D Printed Ceramic Scaffolds
title Bone Regeneration Capability of 3D Printed Ceramic Scaffolds
title_full Bone Regeneration Capability of 3D Printed Ceramic Scaffolds
title_fullStr Bone Regeneration Capability of 3D Printed Ceramic Scaffolds
title_full_unstemmed Bone Regeneration Capability of 3D Printed Ceramic Scaffolds
title_short Bone Regeneration Capability of 3D Printed Ceramic Scaffolds
title_sort bone regeneration capability of 3d printed ceramic scaffolds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402304/
https://www.ncbi.nlm.nih.gov/pubmed/32650589
http://dx.doi.org/10.3390/ijms21144837
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